Occupational risk factors and prostate cancer in U.S. blacks and whites

Srmena Krstev, Dalsu Baris, Patricia Stewart, Mustafa Dosemeci, G. Marie Swanson, Raymond S. Greenberg, Janet B. Schoenberg, Ann G. Schwartz, Jonathan M. Liff, Richard B. Hayes

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Although prostate cancer is a major disease, causal factors are only partially understood. We examined occupational risk factors for this disease in a large case control study among U.S. blacks and whites. The study included 981 new pathologically confirmed prostate cancer cases (479 blacks and 502 whites) diagnosed between 1986 and 1989, and 1,315 population controls (594 blacks and 721 whites) who resided in Atlanta, Detroit, and 10 counties in New Jersey, covered by population-based cancer registries. Information on occupation, including a lifetime work history, was collected by in-person interview. No clear patterns of risk were found for U.S. whites versus blacks, nor for white-collar versus blue-collar jobs. Farming was related to prostate cancer (OR = 2.17; 95% CI = 1.18-3.98). Risk was restricted, however, to short-term workers and workers in crop production. Risk was not limited to those farming after 1950, when widespread use of pesticides started. Risks increased with increasing years of employment in firefighting (χ2(trend), p = 0.02) and power plant operations (χ2(trend), p = 0.03), and were elevated among long-term railroad line-haulers (OR = 5.85; 95% CI = 1.25-27.4); jobs with potential polycyclic aromatic hydrocarbon (PAH) exposures. Risk was elevated among athletes (OR = 5.38; 95% CI = 1.48-19.6). However, most of the cases were athletes before 1960, so the potential use of anabolic steroids was excluded. Although some clues about potential occupational associations were found, the overall results show that Occupation is not a major determinant of prostate cancer risk.

Original languageEnglish (US)
Pages (from-to)421-430
Number of pages10
JournalAmerican Journal of Industrial Medicine
Volume34
Issue number5
DOIs
StatePublished - Nov 1998
Externally publishedYes

Fingerprint

Prostatic Neoplasms
Agriculture
Occupations
Athletes
Testosterone Congeners
Railroads
Power Plants
Population Control
Polycyclic Aromatic Hydrocarbons
Pesticides
Registries
hydroquinone
Case-Control Studies
Interviews
Population
Neoplasms

Keywords

  • Case control
  • Industry
  • Occupation
  • Prostate cancer

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Krstev, S., Baris, D., Stewart, P., Dosemeci, M., Swanson, G. M., Greenberg, R. S., ... Hayes, R. B. (1998). Occupational risk factors and prostate cancer in U.S. blacks and whites. American Journal of Industrial Medicine, 34(5), 421-430. https://doi.org/10.1002/(SICI)1097-0274(199811)34:5<421::AID-AJIM2>3.0.CO;2-T

Occupational risk factors and prostate cancer in U.S. blacks and whites. / Krstev, Srmena; Baris, Dalsu; Stewart, Patricia; Dosemeci, Mustafa; Swanson, G. Marie; Greenberg, Raymond S.; Schoenberg, Janet B.; Schwartz, Ann G.; Liff, Jonathan M.; Hayes, Richard B.

In: American Journal of Industrial Medicine, Vol. 34, No. 5, 11.1998, p. 421-430.

Research output: Contribution to journalArticle

Krstev, S, Baris, D, Stewart, P, Dosemeci, M, Swanson, GM, Greenberg, RS, Schoenberg, JB, Schwartz, AG, Liff, JM & Hayes, RB 1998, 'Occupational risk factors and prostate cancer in U.S. blacks and whites', American Journal of Industrial Medicine, vol. 34, no. 5, pp. 421-430. https://doi.org/10.1002/(SICI)1097-0274(199811)34:5<421::AID-AJIM2>3.0.CO;2-T
Krstev, Srmena ; Baris, Dalsu ; Stewart, Patricia ; Dosemeci, Mustafa ; Swanson, G. Marie ; Greenberg, Raymond S. ; Schoenberg, Janet B. ; Schwartz, Ann G. ; Liff, Jonathan M. ; Hayes, Richard B. / Occupational risk factors and prostate cancer in U.S. blacks and whites. In: American Journal of Industrial Medicine. 1998 ; Vol. 34, No. 5. pp. 421-430.
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