Ochrobactrum anthropi meningitis in pediatric pericardial allograft transplant recipients

Huan J. Chang, John C. Christenson, Andrew T. Pavia, Brad D. Bobrin, A. Lee Bland, Loretta A. Carson, Matthew J. Arduino, Punam Verma, Sonia M. Aguero, Karen Carroll, Eileen Jenkins, Judy A. Daly, Marion L. Woods, William R. Jarvis

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

An epidemiologic investigation was done after 3 patients contracted Ochrobactrum anthropi meningitis at one hospital in October 1994. Neurosurgical patients with pericardial tissue implants were at greater risk of infection than other neurosurgical patients (3/14 vs. 0/566; P < .001). Cultures of implants removed from 2 case-patients, an implant at implantation, a nonimplanted pericardial tissue, and an unwrapped but unopened bottle of Hanks' balanced salt solution (HBSS) grew O. anthropi. Patient and tissue isolates had identical genotypes; the isolate from the HBSS bottle had a unique genotype. Culture samples from an unopened HBSS bottle and from pericardial tissue grew Pseudomonas stutzeri of the same genotype; however, no P. stutzeri infections were detected. The investigation documented intrinsic P. stutzeri contamination of HBSS. O. anthropi contamination of tissues occurred during processing, possibly due to extrinsic contamination of HBSS. Active surveillance is needed to detect infection in patients receiving transplanted tissues, and rigorous infection control practices are necessary during tissue harvesting and processing to ensure sterility.

Original languageEnglish (US)
Pages (from-to)656-660
Number of pages5
JournalJournal of Infectious Diseases
Volume173
Issue number3
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Chang, H. J., Christenson, J. C., Pavia, A. T., Bobrin, B. D., Bland, A. L., Carson, L. A., Arduino, M. J., Verma, P., Aguero, S. M., Carroll, K., Jenkins, E., Daly, J. A., Woods, M. L., & Jarvis, W. R. (1996). Ochrobactrum anthropi meningitis in pediatric pericardial allograft transplant recipients. Journal of Infectious Diseases, 173(3), 656-660. https://doi.org/10.1093/infdis/173.3.656