Ocular aminopeptidase activity and distribution in the albino rabbit

Robert E. Stratford, Vincent H.L. Lee

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Ocular aminopeptidase activity in the albino rabbit was determined using L-leucine-, L-alanine-, and L-arginine-4-methoxy-2-naphthylamide as substrates. The corneal epithelium and the irisciliary body were found to be the most active, followed by, in turn, conjunctiva and corneal stroma, lens and aqueous humor, and lastly tears. The pattern of substrate hydrolysis suggests that a common dominant aminopeptidase is present in these tissues except the conjunctiva. While the role of these peptidases in ocular physiology is unknown, they may play a role in limiting the entry of topically applied peptides into the eye.

Original languageEnglish (US)
Pages (from-to)995-1000
Number of pages6
JournalCurrent Eye Research
Volume4
Issue number9
DOIs
StatePublished - Jan 1 1985

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ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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