Ocular aminopeptidase activity and distribution in the albino rabbit

Robert E. Stratford, Vincent H.L. Lee

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Ocular aminopeptidase activity in the albino rabbit was determined using L-leucine-, L-alanine-, and L-arginine-4-methoxy-2-naphthylamide as substrates. The corneal epithelium and the irisciliary body were found to be the most active, followed by, in turn, conjunctiva and corneal stroma, lens and aqueous humor, and lastly tears. The pattern of substrate hydrolysis suggests that a common dominant aminopeptidase is present in these tissues except the conjunctiva. While the role of these peptidases in ocular physiology is unknown, they may play a role in limiting the entry of topically applied peptides into the eye.

Original languageEnglish (US)
Pages (from-to)995-1000
Number of pages6
JournalCurrent Eye Research
Volume4
Issue number9
DOIs
StatePublished - Jan 1 1985

Fingerprint

Aminopeptidases
Conjunctiva
Ocular Physiological Phenomena
Rabbits
Corneal Stroma
Corneal Epithelium
Aqueous Humor
Tears
Leucine
Alanine
Lenses
Arginine
Hydrolysis
Peptide Hydrolases
Peptides
2-naphthylamide

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Ocular aminopeptidase activity and distribution in the albino rabbit. / Stratford, Robert E.; Lee, Vincent H.L.

In: Current Eye Research, Vol. 4, No. 9, 01.01.1985, p. 995-1000.

Research output: Contribution to journalArticle

@article{c31753f1ba7c4472b49475791181a294,
title = "Ocular aminopeptidase activity and distribution in the albino rabbit",
abstract = "Ocular aminopeptidase activity in the albino rabbit was determined using L-leucine-, L-alanine-, and L-arginine-4-methoxy-2-naphthylamide as substrates. The corneal epithelium and the irisciliary body were found to be the most active, followed by, in turn, conjunctiva and corneal stroma, lens and aqueous humor, and lastly tears. The pattern of substrate hydrolysis suggests that a common dominant aminopeptidase is present in these tissues except the conjunctiva. While the role of these peptidases in ocular physiology is unknown, they may play a role in limiting the entry of topically applied peptides into the eye.",
author = "Stratford, {Robert E.} and Lee, {Vincent H.L.}",
year = "1985",
month = "1",
day = "1",
doi = "10.3109/02713689509000007",
language = "English (US)",
volume = "4",
pages = "995--1000",
journal = "Current Eye Research",
issn = "0271-3683",
publisher = "Informa Healthcare",
number = "9",

}

TY - JOUR

T1 - Ocular aminopeptidase activity and distribution in the albino rabbit

AU - Stratford, Robert E.

AU - Lee, Vincent H.L.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Ocular aminopeptidase activity in the albino rabbit was determined using L-leucine-, L-alanine-, and L-arginine-4-methoxy-2-naphthylamide as substrates. The corneal epithelium and the irisciliary body were found to be the most active, followed by, in turn, conjunctiva and corneal stroma, lens and aqueous humor, and lastly tears. The pattern of substrate hydrolysis suggests that a common dominant aminopeptidase is present in these tissues except the conjunctiva. While the role of these peptidases in ocular physiology is unknown, they may play a role in limiting the entry of topically applied peptides into the eye.

AB - Ocular aminopeptidase activity in the albino rabbit was determined using L-leucine-, L-alanine-, and L-arginine-4-methoxy-2-naphthylamide as substrates. The corneal epithelium and the irisciliary body were found to be the most active, followed by, in turn, conjunctiva and corneal stroma, lens and aqueous humor, and lastly tears. The pattern of substrate hydrolysis suggests that a common dominant aminopeptidase is present in these tissues except the conjunctiva. While the role of these peptidases in ocular physiology is unknown, they may play a role in limiting the entry of topically applied peptides into the eye.

UR - http://www.scopus.com/inward/record.url?scp=0022363814&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022363814&partnerID=8YFLogxK

U2 - 10.3109/02713689509000007

DO - 10.3109/02713689509000007

M3 - Article

C2 - 4064737

AN - SCOPUS:0022363814

VL - 4

SP - 995

EP - 1000

JO - Current Eye Research

JF - Current Eye Research

SN - 0271-3683

IS - 9

ER -