Ocular changes in traumatic brain injury: A review

Osama Mufti, Sunu Mathew, Alon Harris, Brent Siesky, Kendall M. Burgett, Alice Chandra Verticchio Vercellin

Research output: Contribution to journalReview article

Abstract

Traumatic brain injury is represented by a penetrating or non-penetrating head injury, which causes disruption in the normal functioning of the brain. Traumatic brain injury has been an ardently debated topic of discussion due to its prevalence in media centric persons such as military personnel and athletes. Current assessments for traumatic brain injury have looked at vestibulo-ocular and vascular parameters to aid in diagnosis. Innovations in non-invasive ophthalmic imaging have allowed for the visualization of specific tissue structure/function relationships in a variety of ophthalmic and neurodegenerative diseases. As the eye and brain share significant embryological and physiological pathways, ocular imaging modalities may provide a novel and impactful tool in advancing assessment of traumatic brain injury. Herein, we examined the available literature and data on visual fields, mean retinal nerve fiber layer thickness, retinal ganglion cell layer thickness, and cerebral blood flow following traumatic brain injury. This review of published individual and population-based studies was performed in order to explore the feasibility and importance of considering ocular imaging biomarkers following traumatic brain injury.

Original languageEnglish (US)
JournalEuropean Journal of Ophthalmology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Cerebrovascular Circulation
Eye Diseases
Retinal Ganglion Cells
Military Personnel
Brain
Visual Fields
Craniocerebral Trauma
Nerve Fibers
Athletes
Neurodegenerative Diseases
Blood Vessels
Traumatic Brain Injury
Biomarkers
Population

Keywords

  • anatomy/biochemistry/physiology
  • Neuroimaging
  • posterior segment complications of trauma
  • retina
  • trauma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ocular changes in traumatic brain injury : A review. / Mufti, Osama; Mathew, Sunu; Harris, Alon; Siesky, Brent; Burgett, Kendall M.; Verticchio Vercellin, Alice Chandra.

In: European Journal of Ophthalmology, 01.01.2019.

Research output: Contribution to journalReview article

Mufti, Osama ; Mathew, Sunu ; Harris, Alon ; Siesky, Brent ; Burgett, Kendall M. ; Verticchio Vercellin, Alice Chandra. / Ocular changes in traumatic brain injury : A review. In: European Journal of Ophthalmology. 2019.
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