Ocular circulation in systemic lupus erythematosus

Monika Modrzejewska, Lidia Ostanek, Danuta Bobrowska-Snarska, Danuta Karczewicz, Grazyna Wilk, Marek Brzosko, Alon Harris

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Mean vascular resistance in the retrobulbar arteries of SLE patients and the statistical relationship between its parameters and the presence of certain antibodies were determined. Material/Methods: Forty-three eyes of 43 SLE female patients aged 46.28±8.45 years with disease duration of 10.03±7.96 years were examined. Physical and ophthalmic examinations with assessments of the immunological markers ANA/IgG-IgM, aCL, anti-b2GPI, LA, and anti-dsDNA antibodies were performed. color Doppler imaging (CDI) was used in the OA, CRA, LPCA, and MPCA vessels. The vascular resistance indices (RIs) were compared with those of 43 eyes of 43 female controls. Covariance and multiple regression analysis with chi squared, Pearson, Shapiro-Wilk, and Levene tests were used in the statistical analysis (significance levels at p≤ 0.01 and p≤0.05). Results: Significantly increased RIs in the OA, CRA, LPCA, and MPCA were recorded. aCL, aβ2GPI, and LAC correlated significantly with increased RI in the CRA. SLE diagnosis significantly correlated with RI in the OA and PCAs. Significant relationship between age and RI in the CRA and LPCA was detected. Conclusions: Retrobulbar resistance disturbances were detected in SLE patients by CDI. SLE diagnoses and presence of aPLs antibodies were associated with an increased resistivity index in ophthalmic and retinochoroidal vessels.

Original languageEnglish
JournalMedical Science Monitor
Volume15
Issue number11
StatePublished - Nov 2009

Fingerprint

Systemic Lupus Erythematosus
Vascular Resistance
Color
Passive Cutaneous Anaphylaxis
Antibodies
Physical Examination
Anti-Idiotypic Antibodies
Arteries
Immunoglobulin G
Regression Analysis

Keywords

  • Antinuclear antibodies
  • Color Doppler imaging
  • Retrobulbar circulation
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Modrzejewska, M., Ostanek, L., Bobrowska-Snarska, D., Karczewicz, D., Wilk, G., Brzosko, M., & Harris, A. (2009). Ocular circulation in systemic lupus erythematosus. Medical Science Monitor, 15(11).

Ocular circulation in systemic lupus erythematosus. / Modrzejewska, Monika; Ostanek, Lidia; Bobrowska-Snarska, Danuta; Karczewicz, Danuta; Wilk, Grazyna; Brzosko, Marek; Harris, Alon.

In: Medical Science Monitor, Vol. 15, No. 11, 11.2009.

Research output: Contribution to journalArticle

Modrzejewska, M, Ostanek, L, Bobrowska-Snarska, D, Karczewicz, D, Wilk, G, Brzosko, M & Harris, A 2009, 'Ocular circulation in systemic lupus erythematosus', Medical Science Monitor, vol. 15, no. 11.
Modrzejewska M, Ostanek L, Bobrowska-Snarska D, Karczewicz D, Wilk G, Brzosko M et al. Ocular circulation in systemic lupus erythematosus. Medical Science Monitor. 2009 Nov;15(11).
Modrzejewska, Monika ; Ostanek, Lidia ; Bobrowska-Snarska, Danuta ; Karczewicz, Danuta ; Wilk, Grazyna ; Brzosko, Marek ; Harris, Alon. / Ocular circulation in systemic lupus erythematosus. In: Medical Science Monitor. 2009 ; Vol. 15, No. 11.
@article{7fdd8f48b91f4ee2b531722a1cc3b6d5,
title = "Ocular circulation in systemic lupus erythematosus",
abstract = "Background: Mean vascular resistance in the retrobulbar arteries of SLE patients and the statistical relationship between its parameters and the presence of certain antibodies were determined. Material/Methods: Forty-three eyes of 43 SLE female patients aged 46.28±8.45 years with disease duration of 10.03±7.96 years were examined. Physical and ophthalmic examinations with assessments of the immunological markers ANA/IgG-IgM, aCL, anti-b2GPI, LA, and anti-dsDNA antibodies were performed. color Doppler imaging (CDI) was used in the OA, CRA, LPCA, and MPCA vessels. The vascular resistance indices (RIs) were compared with those of 43 eyes of 43 female controls. Covariance and multiple regression analysis with chi squared, Pearson, Shapiro-Wilk, and Levene tests were used in the statistical analysis (significance levels at p≤ 0.01 and p≤0.05). Results: Significantly increased RIs in the OA, CRA, LPCA, and MPCA were recorded. aCL, aβ2GPI, and LAC correlated significantly with increased RI in the CRA. SLE diagnosis significantly correlated with RI in the OA and PCAs. Significant relationship between age and RI in the CRA and LPCA was detected. Conclusions: Retrobulbar resistance disturbances were detected in SLE patients by CDI. SLE diagnoses and presence of aPLs antibodies were associated with an increased resistivity index in ophthalmic and retinochoroidal vessels.",
keywords = "Antinuclear antibodies, Color Doppler imaging, Retrobulbar circulation, Systemic lupus erythematosus",
author = "Monika Modrzejewska and Lidia Ostanek and Danuta Bobrowska-Snarska and Danuta Karczewicz and Grazyna Wilk and Marek Brzosko and Alon Harris",
year = "2009",
month = "11",
language = "English",
volume = "15",
journal = "Medical Science Monitor",
issn = "1234-1010",
publisher = "International Scientific Literature Inc.",
number = "11",

}

TY - JOUR

T1 - Ocular circulation in systemic lupus erythematosus

AU - Modrzejewska, Monika

AU - Ostanek, Lidia

AU - Bobrowska-Snarska, Danuta

AU - Karczewicz, Danuta

AU - Wilk, Grazyna

AU - Brzosko, Marek

AU - Harris, Alon

PY - 2009/11

Y1 - 2009/11

N2 - Background: Mean vascular resistance in the retrobulbar arteries of SLE patients and the statistical relationship between its parameters and the presence of certain antibodies were determined. Material/Methods: Forty-three eyes of 43 SLE female patients aged 46.28±8.45 years with disease duration of 10.03±7.96 years were examined. Physical and ophthalmic examinations with assessments of the immunological markers ANA/IgG-IgM, aCL, anti-b2GPI, LA, and anti-dsDNA antibodies were performed. color Doppler imaging (CDI) was used in the OA, CRA, LPCA, and MPCA vessels. The vascular resistance indices (RIs) were compared with those of 43 eyes of 43 female controls. Covariance and multiple regression analysis with chi squared, Pearson, Shapiro-Wilk, and Levene tests were used in the statistical analysis (significance levels at p≤ 0.01 and p≤0.05). Results: Significantly increased RIs in the OA, CRA, LPCA, and MPCA were recorded. aCL, aβ2GPI, and LAC correlated significantly with increased RI in the CRA. SLE diagnosis significantly correlated with RI in the OA and PCAs. Significant relationship between age and RI in the CRA and LPCA was detected. Conclusions: Retrobulbar resistance disturbances were detected in SLE patients by CDI. SLE diagnoses and presence of aPLs antibodies were associated with an increased resistivity index in ophthalmic and retinochoroidal vessels.

AB - Background: Mean vascular resistance in the retrobulbar arteries of SLE patients and the statistical relationship between its parameters and the presence of certain antibodies were determined. Material/Methods: Forty-three eyes of 43 SLE female patients aged 46.28±8.45 years with disease duration of 10.03±7.96 years were examined. Physical and ophthalmic examinations with assessments of the immunological markers ANA/IgG-IgM, aCL, anti-b2GPI, LA, and anti-dsDNA antibodies were performed. color Doppler imaging (CDI) was used in the OA, CRA, LPCA, and MPCA vessels. The vascular resistance indices (RIs) were compared with those of 43 eyes of 43 female controls. Covariance and multiple regression analysis with chi squared, Pearson, Shapiro-Wilk, and Levene tests were used in the statistical analysis (significance levels at p≤ 0.01 and p≤0.05). Results: Significantly increased RIs in the OA, CRA, LPCA, and MPCA were recorded. aCL, aβ2GPI, and LAC correlated significantly with increased RI in the CRA. SLE diagnosis significantly correlated with RI in the OA and PCAs. Significant relationship between age and RI in the CRA and LPCA was detected. Conclusions: Retrobulbar resistance disturbances were detected in SLE patients by CDI. SLE diagnoses and presence of aPLs antibodies were associated with an increased resistivity index in ophthalmic and retinochoroidal vessels.

KW - Antinuclear antibodies

KW - Color Doppler imaging

KW - Retrobulbar circulation

KW - Systemic lupus erythematosus

UR - http://www.scopus.com/inward/record.url?scp=71649091191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71649091191&partnerID=8YFLogxK

M3 - Article

C2 - 19865056

AN - SCOPUS:71649091191

VL - 15

JO - Medical Science Monitor

JF - Medical Science Monitor

SN - 1234-1010

IS - 11

ER -