Ocular hemodynamic effects of acute ethanol ingestion

Alon Harris, Dan Swartz, David Engen, Dennis Beck, David Evans, Karen Caldemeyer, Bruce Martin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: Because the protean biological effects of ethanol include acute alterations in both cortical function and circulatory control, we investigated the effect of acute alcohol consumption on retrobulbar hemodynamics and contrast sensitivity in healthy human volunteers. Subjects and Methods: Twelve young adults received orange juice with and without ethanol in a double-masked fashion. The ethanol dose was sufficient to raise blood alcohol to 0.07 ± 0.003 g/dl. Retrobulbar hemodynamics were assessed at baseline and twice at elevated blood alcohol by color Doppler imaging. Results: Acute elevation of blood alcohol lowered intraocular pressure from 13.0 ± 0.7 to 10.7 ± 0.7 mm Hg (p < 0.05). In contrast, elevated blood alcohol left peak systolic velocity, end-diastolic velocity and the resistance index constant in three retrobulbar arteries (ophthalmic, central retinal and posterior ciliary). For example, in the central retinal artery, peak systolic velocity, enddiastolic velocity and the resistance index averaged 11.0 ± 1.3 cm/s, 2.8 ± 0.4 cm/s and 0.75 ± 0.03 before ethanol, as compared with 10.5 ± 1.0 cm/s, 2.9 ± 0.3 cm/s and 0.72 ± 0.03 after ethanol (all = NS). Alcohol ingestion also failed to alter either visual acuity or contrast sensitivity, as assessed under both photopic and mesopic conditions. Conclusions: Although ethanol has widespread cognitive and cardiovascular effects, at blood levels near legal definitions of intoxication we found it ineffective in altering either retrobulbar hemodynamics or contrast sensitivity.

Original languageEnglish (US)
Pages (from-to)193-200
Number of pages8
JournalOphthalmic Research
Volume28
Issue number3
DOIs
StatePublished - Jan 1 1996

Fingerprint

Ethanol
Eating
Hemodynamics
Alcohols
Contrast Sensitivity
Retinal Artery
Intraocular Pressure
Alcohol Drinking
Visual Acuity
Young Adult
Healthy Volunteers
Color

Keywords

  • Central retinal artery
  • Color Doppler imaging
  • Contrast sensitivity
  • Ophthalmic artery
  • Visual acuity

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Harris, A., Swartz, D., Engen, D., Beck, D., Evans, D., Caldemeyer, K., & Martin, B. (1996). Ocular hemodynamic effects of acute ethanol ingestion. Ophthalmic Research, 28(3), 193-200. https://doi.org/10.1159/000267902

Ocular hemodynamic effects of acute ethanol ingestion. / Harris, Alon; Swartz, Dan; Engen, David; Beck, Dennis; Evans, David; Caldemeyer, Karen; Martin, Bruce.

In: Ophthalmic Research, Vol. 28, No. 3, 01.01.1996, p. 193-200.

Research output: Contribution to journalArticle

Harris, A, Swartz, D, Engen, D, Beck, D, Evans, D, Caldemeyer, K & Martin, B 1996, 'Ocular hemodynamic effects of acute ethanol ingestion', Ophthalmic Research, vol. 28, no. 3, pp. 193-200. https://doi.org/10.1159/000267902
Harris A, Swartz D, Engen D, Beck D, Evans D, Caldemeyer K et al. Ocular hemodynamic effects of acute ethanol ingestion. Ophthalmic Research. 1996 Jan 1;28(3):193-200. https://doi.org/10.1159/000267902
Harris, Alon ; Swartz, Dan ; Engen, David ; Beck, Dennis ; Evans, David ; Caldemeyer, Karen ; Martin, Bruce. / Ocular hemodynamic effects of acute ethanol ingestion. In: Ophthalmic Research. 1996 ; Vol. 28, No. 3. pp. 193-200.
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