Ocular hemodynamics and glaucoma: The role of mathematical modeling

Alon Harris, Giovanna Guidoboni, Julia C. Arciero, Annahita Amireskandari, Leslie A. Tobe, Brent A. Siesky

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Purpose. To discuss the role of mathematical modeling in studying ocular hemodynamics, with a focus on glaucoma. Methods. We reviewed recent literature on glaucoma, ocular blood flow, autoregulation, the optic nerve head, and the use of mathematical modeling in ocular circulation. Results. Many studies suggest that alterations in ocular hemodynamics play a significant role in the development, progression, and incidence of glaucoma. Although there is currently a limited number of studies involving mathematical modeling of ocular blood flow, regulation, and diseases (such as glaucoma), preliminary modeling work shows the potential of mathematical models to elucidate the mechanisms that contribute most significantly to glaucoma progression. Conclusion. Mathematical modeling is a useful tool when used synergistically with clinical and laboratory data in the study of ocular blood flow and glaucoma. The development of models to investigate the relationship between ocular hemodynamic alterations and glaucoma progression will provide a unique and useful method for studying the pathophysiology of glaucoma.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalEuropean Journal of Ophthalmology
Volume23
Issue number2
DOIs
StatePublished - Feb 26 2013

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Keywords

  • Glaucoma
  • Mathematical modeling
  • Ocular hemodynamics

ASJC Scopus subject areas

  • Ophthalmology

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