Ocular hemodynamics and glaucoma: The role of mathematical modeling

Alon Harris, Giovanna Guidoboni, Julia C. Arciero, Annahita Amireskandari, Leslie A. Tobe, Brent Siesky

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose. To discuss the role of mathematical modeling in studying ocular hemodynamics, with a focus on glaucoma. Methods. We reviewed recent literature on glaucoma, ocular blood flow, autoregulation, the optic nerve head, and the use of mathematical modeling in ocular circulation. Results. Many studies suggest that alterations in ocular hemodynamics play a significant role in the development, progression, and incidence of glaucoma. Although there is currently a limited number of studies involving mathematical modeling of ocular blood flow, regulation, and diseases (such as glaucoma), preliminary modeling work shows the potential of mathematical models to elucidate the mechanisms that contribute most significantly to glaucoma progression. Conclusion. Mathematical modeling is a useful tool when used synergistically with clinical and laboratory data in the study of ocular blood flow and glaucoma. The development of models to investigate the relationship between ocular hemodynamic alterations and glaucoma progression will provide a unique and useful method for studying the pathophysiology of glaucoma.

Original languageEnglish
Pages (from-to)139-146
Number of pages8
JournalEuropean Journal of Ophthalmology
Volume23
Issue number2
DOIs
StatePublished - 2013

Fingerprint

Glaucoma
Hemodynamics
Optic Disk
Homeostasis
Theoretical Models
Incidence

Keywords

  • Glaucoma
  • Mathematical modeling
  • Ocular hemodynamics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ocular hemodynamics and glaucoma : The role of mathematical modeling. / Harris, Alon; Guidoboni, Giovanna; Arciero, Julia C.; Amireskandari, Annahita; Tobe, Leslie A.; Siesky, Brent.

In: European Journal of Ophthalmology, Vol. 23, No. 2, 2013, p. 139-146.

Research output: Contribution to journalArticle

Harris, Alon ; Guidoboni, Giovanna ; Arciero, Julia C. ; Amireskandari, Annahita ; Tobe, Leslie A. ; Siesky, Brent. / Ocular hemodynamics and glaucoma : The role of mathematical modeling. In: European Journal of Ophthalmology. 2013 ; Vol. 23, No. 2. pp. 139-146.
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