Ocular penetration of levofloxacin, ofloxacin and ciprofloxacin in eyes with functioning filtering blebs: Investigator masked, randomised clinical trial

Louis Cantor, Darrell WuDunn, C. W. Yung, S. Valluri, Yara Catoira-Boyle, J. S. Hoop, L. S. Morgan

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Abstract

Background/aims: To compare the penetration of levofloxacin, ofloxacin and ciprofloxacin in the aqueous humour of eyes with functioning filtering blebs. Methods: In this investigator-masked study, 48 patients with functioning filtering blebs requiring cataract surgery were randomised into six groups of eight patients. Groups 1, 2 and 3 received topical ofloxacin 0.3% (Ocuflox®), ciprofloxacin 0.3% (Ciloxan®) and levofloxacin (Quixin®) respectively; Groups 4, 5 and 6 received the same treatment with the corresponding oral dose of ofloxacin 400 mg (Floxin), ciprofloxacin 400 mg (Cipro) and levofloxacin 250 mg (Levaquin). Aqueous antibiotic levels were determined by mass spectrometry of aqueous samples from each patient. Results: The mean aqueous level for topical levofloxacin was significantly higher than those achieved by topical ofloxacin or ciprofloxacin (p value = 0.02 and 0.01, respectively). The combination of topical and oral levofloxacin was significantly higher than topical levofloxacin alone (p = 0.05) and the ciprofloxacin combination (p = 0.003) but not significantly higher than the ofloxacin combination therapy. Conclusions: Topical levofloxacin penetrates better than ofloxacin or ciprofloxacin into the aqueous of eyes with functioning filtering blebs. The combination of topical and oral levofloxacin may be preferable in the treatment of bleb-associated infections (NCT 00392275; Clinical trials.gov).

Original languageEnglish
Pages (from-to)345-347
Number of pages3
JournalBritish Journal of Ophthalmology
Volume92
Issue number3
DOIs
StatePublished - Mar 2008

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Levofloxacin
Ofloxacin
Blister
Ciprofloxacin
Randomized Controlled Trials
Research Personnel
Aqueous Humor
Cataract
Mass Spectrometry
Therapeutics
Clinical Trials
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ocular penetration of levofloxacin, ofloxacin and ciprofloxacin in eyes with functioning filtering blebs : Investigator masked, randomised clinical trial. / Cantor, Louis; WuDunn, Darrell; Yung, C. W.; Valluri, S.; Catoira-Boyle, Yara; Hoop, J. S.; Morgan, L. S.

In: British Journal of Ophthalmology, Vol. 92, No. 3, 03.2008, p. 345-347.

Research output: Contribution to journalArticle

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