Ocular perfusion abnormalities in diabetes

Thomas A. Ciulla, Alon Harris, Paul Latkany, Heidi C. Piper, Oliver Arend, Hana Garzozi, Bruce Martin

Research output: Contribution to journalReview article

96 Scopus citations

Abstract

Purpose: To review the role of ocular perfusion in the pathophysiology of diabetic retinopathy, one of the leading causes of irreversible blindness in the industrialized world. Methods: We carried out a Medline search of the literature published in English or with English abstracts from 1966 to 2000 using various combinations of relevant key words. Results: Hyperglycaemia leads to a wide variety of vascular abnormalities at the microvascular and macrovascular levels, including abnormal autoregulation. Conclusion: Three major aspects of ocular perfusion in diabetic retinopathy require additional investigation. Firstly, the precise mechanisms that link elevated glucose to dysfunction of retinal vascular cells need to be identified. Secondly, those factors that lead to both capillary dropout and to angiogenesis, twin processes that are linked to tissue hypoxia and lead to excess perfusion, increased risk of extravascular leakage and frank haemorrhage, must be carefully delineated. Finally, once specific knowledge of disease fundamentals has been amassed, tests of therapies to reverse or prevent these pathological processes can move forward.

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Keywords

  • Blood flow
  • Choriocapillaris
  • Choroid
  • Diabetes
  • Diabetic retinopathy
  • Endothelial cel
  • Ocular perfusion
  • Pericyte
  • Retinal circulation

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ciulla, T. A., Harris, A., Latkany, P., Piper, H. C., Arend, O., Garzozi, H., & Martin, B. (2002). Ocular perfusion abnormalities in diabetes. Acta Ophthalmologica Scandinavica, 80(5), 468-477. https://doi.org/10.1034/j.1600-0420.2002.800503.x