Ocular perfusion abnormalities in diabetes

Thomas A. Ciulla, Alon Harris, Paul Latkany, Heidi C. Piper, Oliver Arend, Hana Garzozi, Bruce Martin

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Purpose: To review the role of ocular perfusion in the pathophysiology of diabetic retinopathy, one of the leading causes of irreversible blindness in the industrialized world. Methods: We carried out a Medline search of the literature published in English or with English abstracts from 1966 to 2000 using various combinations of relevant key words. Results: Hyperglycaemia leads to a wide variety of vascular abnormalities at the microvascular and macrovascular levels, including abnormal autoregulation. Conclusion: Three major aspects of ocular perfusion in diabetic retinopathy require additional investigation. Firstly, the precise mechanisms that link elevated glucose to dysfunction of retinal vascular cells need to be identified. Secondly, those factors that lead to both capillary dropout and to angiogenesis, twin processes that are linked to tissue hypoxia and lead to excess perfusion, increased risk of extravascular leakage and frank haemorrhage, must be carefully delineated. Finally, once specific knowledge of disease fundamentals has been amassed, tests of therapies to reverse or prevent these pathological processes can move forward.

Original languageEnglish
Pages (from-to)468-477
Number of pages10
JournalActa Ophthalmologica Scandinavica
Volume80
Issue number5
DOIs
StatePublished - Oct 2002

Fingerprint

Eye Abnormalities
Perfusion
Diabetic Retinopathy
Retinal Vessels
Pathologic Processes
Blindness
Hyperglycemia
Blood Vessels
Homeostasis
Hemorrhage
Glucose
Therapeutics

Keywords

  • Blood flow
  • Choriocapillaris
  • Choroid
  • Diabetes
  • Diabetic retinopathy
  • Endothelial cel
  • Ocular perfusion
  • Pericyte
  • Retinal circulation

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ciulla, T. A., Harris, A., Latkany, P., Piper, H. C., Arend, O., Garzozi, H., & Martin, B. (2002). Ocular perfusion abnormalities in diabetes. Acta Ophthalmologica Scandinavica, 80(5), 468-477. https://doi.org/10.1034/j.1600-0420.2002.800503.x

Ocular perfusion abnormalities in diabetes. / Ciulla, Thomas A.; Harris, Alon; Latkany, Paul; Piper, Heidi C.; Arend, Oliver; Garzozi, Hana; Martin, Bruce.

In: Acta Ophthalmologica Scandinavica, Vol. 80, No. 5, 10.2002, p. 468-477.

Research output: Contribution to journalArticle

Ciulla, TA, Harris, A, Latkany, P, Piper, HC, Arend, O, Garzozi, H & Martin, B 2002, 'Ocular perfusion abnormalities in diabetes', Acta Ophthalmologica Scandinavica, vol. 80, no. 5, pp. 468-477. https://doi.org/10.1034/j.1600-0420.2002.800503.x
Ciulla, Thomas A. ; Harris, Alon ; Latkany, Paul ; Piper, Heidi C. ; Arend, Oliver ; Garzozi, Hana ; Martin, Bruce. / Ocular perfusion abnormalities in diabetes. In: Acta Ophthalmologica Scandinavica. 2002 ; Vol. 80, No. 5. pp. 468-477.
@article{9cb323d0c2c74d7b871869b1e7dddba1,
title = "Ocular perfusion abnormalities in diabetes",
abstract = "Purpose: To review the role of ocular perfusion in the pathophysiology of diabetic retinopathy, one of the leading causes of irreversible blindness in the industrialized world. Methods: We carried out a Medline search of the literature published in English or with English abstracts from 1966 to 2000 using various combinations of relevant key words. Results: Hyperglycaemia leads to a wide variety of vascular abnormalities at the microvascular and macrovascular levels, including abnormal autoregulation. Conclusion: Three major aspects of ocular perfusion in diabetic retinopathy require additional investigation. Firstly, the precise mechanisms that link elevated glucose to dysfunction of retinal vascular cells need to be identified. Secondly, those factors that lead to both capillary dropout and to angiogenesis, twin processes that are linked to tissue hypoxia and lead to excess perfusion, increased risk of extravascular leakage and frank haemorrhage, must be carefully delineated. Finally, once specific knowledge of disease fundamentals has been amassed, tests of therapies to reverse or prevent these pathological processes can move forward.",
keywords = "Blood flow, Choriocapillaris, Choroid, Diabetes, Diabetic retinopathy, Endothelial cel, Ocular perfusion, Pericyte, Retinal circulation",
author = "Ciulla, {Thomas A.} and Alon Harris and Paul Latkany and Piper, {Heidi C.} and Oliver Arend and Hana Garzozi and Bruce Martin",
year = "2002",
month = "10",
doi = "10.1034/j.1600-0420.2002.800503.x",
language = "English",
volume = "80",
pages = "468--477",
journal = "Acta Ophthalmologica",
issn = "1755-375X",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Ocular perfusion abnormalities in diabetes

AU - Ciulla, Thomas A.

AU - Harris, Alon

AU - Latkany, Paul

AU - Piper, Heidi C.

AU - Arend, Oliver

AU - Garzozi, Hana

AU - Martin, Bruce

PY - 2002/10

Y1 - 2002/10

N2 - Purpose: To review the role of ocular perfusion in the pathophysiology of diabetic retinopathy, one of the leading causes of irreversible blindness in the industrialized world. Methods: We carried out a Medline search of the literature published in English or with English abstracts from 1966 to 2000 using various combinations of relevant key words. Results: Hyperglycaemia leads to a wide variety of vascular abnormalities at the microvascular and macrovascular levels, including abnormal autoregulation. Conclusion: Three major aspects of ocular perfusion in diabetic retinopathy require additional investigation. Firstly, the precise mechanisms that link elevated glucose to dysfunction of retinal vascular cells need to be identified. Secondly, those factors that lead to both capillary dropout and to angiogenesis, twin processes that are linked to tissue hypoxia and lead to excess perfusion, increased risk of extravascular leakage and frank haemorrhage, must be carefully delineated. Finally, once specific knowledge of disease fundamentals has been amassed, tests of therapies to reverse or prevent these pathological processes can move forward.

AB - Purpose: To review the role of ocular perfusion in the pathophysiology of diabetic retinopathy, one of the leading causes of irreversible blindness in the industrialized world. Methods: We carried out a Medline search of the literature published in English or with English abstracts from 1966 to 2000 using various combinations of relevant key words. Results: Hyperglycaemia leads to a wide variety of vascular abnormalities at the microvascular and macrovascular levels, including abnormal autoregulation. Conclusion: Three major aspects of ocular perfusion in diabetic retinopathy require additional investigation. Firstly, the precise mechanisms that link elevated glucose to dysfunction of retinal vascular cells need to be identified. Secondly, those factors that lead to both capillary dropout and to angiogenesis, twin processes that are linked to tissue hypoxia and lead to excess perfusion, increased risk of extravascular leakage and frank haemorrhage, must be carefully delineated. Finally, once specific knowledge of disease fundamentals has been amassed, tests of therapies to reverse or prevent these pathological processes can move forward.

KW - Blood flow

KW - Choriocapillaris

KW - Choroid

KW - Diabetes

KW - Diabetic retinopathy

KW - Endothelial cel

KW - Ocular perfusion

KW - Pericyte

KW - Retinal circulation

UR - http://www.scopus.com/inward/record.url?scp=0036772397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036772397&partnerID=8YFLogxK

U2 - 10.1034/j.1600-0420.2002.800503.x

DO - 10.1034/j.1600-0420.2002.800503.x

M3 - Article

VL - 80

SP - 468

EP - 477

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

SN - 1755-375X

IS - 5

ER -