Ocular perfusion and age-related macular degeneration

T. A. Ciulla, A. Harris, B. J. Martin

Research output: Contribution to journalReview article

48 Scopus citations


Purpose: To review the role of ocular perfusion in the pathophysiology of age-related macular degeneration (AMD), the leading cause of irreversible blindness in the industrialized world. Methods: Medline search of the literature published in English or with English abstracts from 1966 to 2000 was performed using various combinations of relevant key words. Results: Vascular defects have been identified in both nonexudative and exudative AMD patients using fluorescein angiographic methods, laser Doppler flowmetry, indocyanine green angiography, and color Doppler imaging. Conclusion: Although these studies lend some support to the vascular pathogenesis of AMD, it is not possible to determine if the choroidal perfusion abnormalities play a causative role in nonexudative AMD, if they are simply an association with another primary alteration, such as a primary RPE defect or a genetic defect at the photoreceptor level, or if they are more strongly associated with one particular form of this heterogeneous disease. Further study is warranted.

Original languageEnglish (US)
Pages (from-to)108-115
Number of pages8
JournalActa Ophthalmologica Scandinavica
Issue number2
StatePublished - Apr 11 2001


  • Age-related macular degeneration
  • Blood flow
  • Choriocapillaris
  • Choriod
  • Ocular perfusion
  • Retinal circulation

ASJC Scopus subject areas

  • Ophthalmology

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