Ocular perfusion pressure in glaucoma

Vital P. Costa, Alon Harris, Douglas Anderson, Richard Stodtmeister, Fernanda Cremasco, Helene Kergoat, John Lovasik, Ingborg Stalmans, Oliver Zeitz, Ines Lanzl, Konstantin Gugleta, Leopold Schmetterer

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

This review article discusses the relationship between ocular perfusion pressure and glaucoma, including its definition, factors that influence its calculation and epidemiological studies investigating the influence of ocular perfusion pressure on the prevalence, incidence and progression of glaucoma. We also list the possible mechanisms behind this association, and discuss whether it is secondary to changes in intraocular pressure, blood pressure or both. Finally, we describe the circadian variation of ocular perfusion pressure and the effects of systemic and topical medications on it. We believe that the balance between IOP and BP, influenced by the autoregulatory capacity of the eye, is part of what determines whether an individual will develop optic nerve damage. However, prospective, longitudinal studies are needed to better define the role of ocular perfusion pressure in the development and progression of glaucoma.

Original languageEnglish
JournalActa Ophthalmologica
Volume92
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Glaucoma
Perfusion
Pressure
Optic Nerve
Intraocular Pressure
Longitudinal Studies
Epidemiologic Studies
Prospective Studies
Blood Pressure
Incidence

Keywords

  • blood pressure
  • glaucoma risk factors
  • ocular perfusion pressure
  • optic nerve blood flow

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)

Cite this

Costa, V. P., Harris, A., Anderson, D., Stodtmeister, R., Cremasco, F., Kergoat, H., ... Schmetterer, L. (2014). Ocular perfusion pressure in glaucoma. Acta Ophthalmologica, 92(4). https://doi.org/10.1111/aos.12298

Ocular perfusion pressure in glaucoma. / Costa, Vital P.; Harris, Alon; Anderson, Douglas; Stodtmeister, Richard; Cremasco, Fernanda; Kergoat, Helene; Lovasik, John; Stalmans, Ingborg; Zeitz, Oliver; Lanzl, Ines; Gugleta, Konstantin; Schmetterer, Leopold.

In: Acta Ophthalmologica, Vol. 92, No. 4, 2014.

Research output: Contribution to journalArticle

Costa, VP, Harris, A, Anderson, D, Stodtmeister, R, Cremasco, F, Kergoat, H, Lovasik, J, Stalmans, I, Zeitz, O, Lanzl, I, Gugleta, K & Schmetterer, L 2014, 'Ocular perfusion pressure in glaucoma', Acta Ophthalmologica, vol. 92, no. 4. https://doi.org/10.1111/aos.12298
Costa VP, Harris A, Anderson D, Stodtmeister R, Cremasco F, Kergoat H et al. Ocular perfusion pressure in glaucoma. Acta Ophthalmologica. 2014;92(4). https://doi.org/10.1111/aos.12298
Costa, Vital P. ; Harris, Alon ; Anderson, Douglas ; Stodtmeister, Richard ; Cremasco, Fernanda ; Kergoat, Helene ; Lovasik, John ; Stalmans, Ingborg ; Zeitz, Oliver ; Lanzl, Ines ; Gugleta, Konstantin ; Schmetterer, Leopold. / Ocular perfusion pressure in glaucoma. In: Acta Ophthalmologica. 2014 ; Vol. 92, No. 4.
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