Olfactory identification in subjective cognitive decline and mild cognitive impairment: Association with tau but not amyloid positron emission tomography

Shannon L. Risacher, Eileen F. Tallman, John D. West, Karmen Yoder, Gary Hutchins, James Fletcher, Sujuan Gao, David Kareken, Martin Farlow, Liana G. Apostolova, Andrew Saykin

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction We investigated the association between olfactory identification and Alzheimer's disease biomarkers, including amyloid, tau, and neurodegeneration. Methods Thirty-four older adults, including 19 cognitively normal (CN), 10 subjective cognitive decline (SCD), and 5 mild cognitive impairment, underwent amyloid positron emission tomography, magnetic resonance imaging, and the University of Pennsylvania Smell Identification Test (UPSIT). Twenty-six also underwent tau positron emission tomography. Associations between the UPSIT and regionally sampled amyloid, tau, and temporal atrophy were evaluated. Voxel-wise regression models were also utilized. Analyses were conducted with the full sample and only CN/SCD. Results Lower UPSIT scores were associated with increased temporal and parietal tau burden in regional and voxel-wise analyses in the full sample and in CN and SCD only. Temporal lobe atrophy was associated with lower UPSIT score. Amyloid was not associated with the UPSIT. Discussion Impairment on the UPSIT may be a good marker for tau and neurodegeneration in preclinical or prodromal Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)57-66
Number of pages10
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume9
DOIs
StatePublished - 2017

Fingerprint

Smell
Amyloid
Positron-Emission Tomography
Atrophy
Alzheimer Disease
Temporal Lobe
Cognitive Dysfunction
Biomarkers
Magnetic Resonance Imaging

Keywords

  • Alzheimer's disease
  • Neurodegeneration
  • Olfaction
  • Tau
  • [F]Flortaucipir (AV-1451)

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

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title = "Olfactory identification in subjective cognitive decline and mild cognitive impairment: Association with tau but not amyloid positron emission tomography",
abstract = "Introduction We investigated the association between olfactory identification and Alzheimer's disease biomarkers, including amyloid, tau, and neurodegeneration. Methods Thirty-four older adults, including 19 cognitively normal (CN), 10 subjective cognitive decline (SCD), and 5 mild cognitive impairment, underwent amyloid positron emission tomography, magnetic resonance imaging, and the University of Pennsylvania Smell Identification Test (UPSIT). Twenty-six also underwent tau positron emission tomography. Associations between the UPSIT and regionally sampled amyloid, tau, and temporal atrophy were evaluated. Voxel-wise regression models were also utilized. Analyses were conducted with the full sample and only CN/SCD. Results Lower UPSIT scores were associated with increased temporal and parietal tau burden in regional and voxel-wise analyses in the full sample and in CN and SCD only. Temporal lobe atrophy was associated with lower UPSIT score. Amyloid was not associated with the UPSIT. Discussion Impairment on the UPSIT may be a good marker for tau and neurodegeneration in preclinical or prodromal Alzheimer's disease.",
keywords = "Alzheimer's disease, Neurodegeneration, Olfaction, Tau, [F]Flortaucipir (AV-1451)",
author = "Risacher, {Shannon L.} and Tallman, {Eileen F.} and West, {John D.} and Karmen Yoder and Gary Hutchins and James Fletcher and Sujuan Gao and David Kareken and Martin Farlow and Apostolova, {Liana G.} and Andrew Saykin",
year = "2017",
doi = "10.1016/j.dadm.2017.09.001",
language = "English (US)",
volume = "9",
pages = "57--66",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
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TY - JOUR

T1 - Olfactory identification in subjective cognitive decline and mild cognitive impairment

T2 - Association with tau but not amyloid positron emission tomography

AU - Risacher, Shannon L.

AU - Tallman, Eileen F.

AU - West, John D.

AU - Yoder, Karmen

AU - Hutchins, Gary

AU - Fletcher, James

AU - Gao, Sujuan

AU - Kareken, David

AU - Farlow, Martin

AU - Apostolova, Liana G.

AU - Saykin, Andrew

PY - 2017

Y1 - 2017

N2 - Introduction We investigated the association between olfactory identification and Alzheimer's disease biomarkers, including amyloid, tau, and neurodegeneration. Methods Thirty-four older adults, including 19 cognitively normal (CN), 10 subjective cognitive decline (SCD), and 5 mild cognitive impairment, underwent amyloid positron emission tomography, magnetic resonance imaging, and the University of Pennsylvania Smell Identification Test (UPSIT). Twenty-six also underwent tau positron emission tomography. Associations between the UPSIT and regionally sampled amyloid, tau, and temporal atrophy were evaluated. Voxel-wise regression models were also utilized. Analyses were conducted with the full sample and only CN/SCD. Results Lower UPSIT scores were associated with increased temporal and parietal tau burden in regional and voxel-wise analyses in the full sample and in CN and SCD only. Temporal lobe atrophy was associated with lower UPSIT score. Amyloid was not associated with the UPSIT. Discussion Impairment on the UPSIT may be a good marker for tau and neurodegeneration in preclinical or prodromal Alzheimer's disease.

AB - Introduction We investigated the association between olfactory identification and Alzheimer's disease biomarkers, including amyloid, tau, and neurodegeneration. Methods Thirty-four older adults, including 19 cognitively normal (CN), 10 subjective cognitive decline (SCD), and 5 mild cognitive impairment, underwent amyloid positron emission tomography, magnetic resonance imaging, and the University of Pennsylvania Smell Identification Test (UPSIT). Twenty-six also underwent tau positron emission tomography. Associations between the UPSIT and regionally sampled amyloid, tau, and temporal atrophy were evaluated. Voxel-wise regression models were also utilized. Analyses were conducted with the full sample and only CN/SCD. Results Lower UPSIT scores were associated with increased temporal and parietal tau burden in regional and voxel-wise analyses in the full sample and in CN and SCD only. Temporal lobe atrophy was associated with lower UPSIT score. Amyloid was not associated with the UPSIT. Discussion Impairment on the UPSIT may be a good marker for tau and neurodegeneration in preclinical or prodromal Alzheimer's disease.

KW - Alzheimer's disease

KW - Neurodegeneration

KW - Olfaction

KW - Tau

KW - [F]Flortaucipir (AV-1451)

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