Oligoclonal IgG in multiple sclerosis and subacute sclerosing panencephalitis brains

David Mattson, Raymond P. Roos, Barry G W Arnason

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

IgG was obtained from multiple sclerosis (MS) and subacute sclerosing panencephalitis (SSPE) brain materials by elution at neutral and acid pH, and by freezing and thawing. Serum, cerebrospinal fluid (CSF), and brain eluates were compared by isoelectric focussing (IEF) with sensitive peroxidase-anti-IgG staining. In 3 MS cases, different plaques or regions of the same brain had IgG patterns with some common and some different bands. Pooled white matter eluates contained the summation of bands seen in individual plaques or regions. Comparison of serum, CSF, and neutral and acid brain eluate IgG patterns showed many common bands but also unique bands. In two SSPE cases, eluates from different regions of the same brain showed virtually identical IgG patterns. Comparisons of serum, CSF, and neutral and acid eluates of the same brain also showed a common pattern of bands. Similarities in IgG patterns of sera, CSF, and regional brain eluates, from single cases of SSPE, suggest a common response to the same antigen in all regions or compartments. Differences in IgG patterns of sera, CSF, pooled brain eluates, and plaques or regional eluates from single cases of MS, suggest: either that (a) all MS oligoclonal IgG is 'nonsense' antibody in terms of disease pathogenesis, or (b) much of the MS oligoclonal IgG is 'nonsense' antibody, present as part of a specific oligoclonal immune reaction.

Original languageEnglish (US)
Pages (from-to)261-276
Number of pages16
JournalJournal of Neuroimmunology
Volume2
Issue number3-4
DOIs
StatePublished - 1982
Externally publishedYes

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Oligoclonal Bands
Subacute Sclerosing Panencephalitis
Multiple Sclerosis
Immunoglobulin G
Cerebrospinal Fluid
Brain
Serum
Acids
Antibodies
Isoelectric Focusing
Freezing
Peroxidase
Staining and Labeling
Antigens

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

Oligoclonal IgG in multiple sclerosis and subacute sclerosing panencephalitis brains. / Mattson, David; Roos, Raymond P.; Arnason, Barry G W.

In: Journal of Neuroimmunology, Vol. 2, No. 3-4, 1982, p. 261-276.

Research output: Contribution to journalArticle

Mattson, David ; Roos, Raymond P. ; Arnason, Barry G W. / Oligoclonal IgG in multiple sclerosis and subacute sclerosing panencephalitis brains. In: Journal of Neuroimmunology. 1982 ; Vol. 2, No. 3-4. pp. 261-276.
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