Oligometastases in Genitourinary Tumors: Recent Insights and Future Molecular Diagnostic Approach

Alessandro Conti, Carolina D'Elia, Monica Cheng, Matteo Santoni, Francesco Piva, Matteo Brunelli, Antonio Lopez-Beltran, Matteo Giulietti, Marina Scarpelli, Armin Pycha, Andrea Benedetto Galosi, Walter Artibani, Liang Cheng, Rodolfo Montironi, Nicola Battelli, Lukas Lusuardi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Context: An oligometastatic state is an early event during tumor metastatic spread and is rarely reported in patients with genitourinary tumors. In this condition, the primary tumor has low capacity for distal dissemination because its aggressiveness has not yet reached a maximum. Objective: To review recent findings on the diagnosis and treatment of oligometastatic disease in patients with genitourinary tumors. Evidence acquisition: To identify relevant studies, we reviewed articles in PubMed from January 1966 to September 2017. The search was conducted by combining the words "oligometastasis" or "oligometastatic disease" with "bladder cancer", "genitourinary tumor", "prostate cancer", and "renal cancer". Evidence synthesis: In renal cell carcinoma (RCC), tumors from patients with multiple metastases showed a different gene signature compared to oligometastatic RCC. In addition, an oligometastatic state was an independent prognostic factor for overall survival (OS). Otherwise, the characteristics of oligometastases from bladder cancer remain unclear, as do the clinical and prognostic significance of metastasectomy in this setting. However, patients with oligometastatic prostate cancer have longer recurrence-free survival and OS and seem to benefit from local metastasis-directed therapies. Conclusions: Early detection of oligometastatic disease in patients with genitourinary tumors is fundamental in improving outcomes by identifying patients who would benefit from local approaches with potentially curative rather than palliative intent. Patients with oligometastases in genitourinary tumors show longer survival because of generally lower tumor aggressiveness and potential eligibility for local approaches. Emerging molecular diagnostic techniques will allow early diagnosis of the oligometastatic state and consequently improve patient outcomes.

Original languageEnglish (US)
JournalEuropean Urology, Supplements
DOIs
StateAccepted/In press - 2017

Fingerprint

Molecular Pathology
Neoplasms
Survival
Renal Cell Carcinoma
Urinary Bladder Neoplasms
Early Diagnosis
Prostatic Neoplasms
Molecular Diagnostic Techniques
Metastasectomy
Neoplasm Metastasis
Kidney Neoplasms
PubMed
Recurrence

Keywords

  • Bladder cancer
  • Early diagnosis
  • Genitourinary tumors
  • Kidney cancer
  • Oligometastasis
  • Prostate cancer

ASJC Scopus subject areas

  • Urology

Cite this

Oligometastases in Genitourinary Tumors : Recent Insights and Future Molecular Diagnostic Approach. / Conti, Alessandro; D'Elia, Carolina; Cheng, Monica; Santoni, Matteo; Piva, Francesco; Brunelli, Matteo; Lopez-Beltran, Antonio; Giulietti, Matteo; Scarpelli, Marina; Pycha, Armin; Galosi, Andrea Benedetto; Artibani, Walter; Cheng, Liang; Montironi, Rodolfo; Battelli, Nicola; Lusuardi, Lukas.

In: European Urology, Supplements, 2017.

Research output: Contribution to journalArticle

Conti, A, D'Elia, C, Cheng, M, Santoni, M, Piva, F, Brunelli, M, Lopez-Beltran, A, Giulietti, M, Scarpelli, M, Pycha, A, Galosi, AB, Artibani, W, Cheng, L, Montironi, R, Battelli, N & Lusuardi, L 2017, 'Oligometastases in Genitourinary Tumors: Recent Insights and Future Molecular Diagnostic Approach', European Urology, Supplements. https://doi.org/10.1016/j.eursup.2017.09.005
Conti, Alessandro ; D'Elia, Carolina ; Cheng, Monica ; Santoni, Matteo ; Piva, Francesco ; Brunelli, Matteo ; Lopez-Beltran, Antonio ; Giulietti, Matteo ; Scarpelli, Marina ; Pycha, Armin ; Galosi, Andrea Benedetto ; Artibani, Walter ; Cheng, Liang ; Montironi, Rodolfo ; Battelli, Nicola ; Lusuardi, Lukas. / Oligometastases in Genitourinary Tumors : Recent Insights and Future Molecular Diagnostic Approach. In: European Urology, Supplements. 2017.
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AU - Conti, Alessandro

AU - D'Elia, Carolina

AU - Cheng, Monica

AU - Santoni, Matteo

AU - Piva, Francesco

AU - Brunelli, Matteo

AU - Lopez-Beltran, Antonio

AU - Giulietti, Matteo

AU - Scarpelli, Marina

AU - Pycha, Armin

AU - Galosi, Andrea Benedetto

AU - Artibani, Walter

AU - Cheng, Liang

AU - Montironi, Rodolfo

AU - Battelli, Nicola

AU - Lusuardi, Lukas

PY - 2017

Y1 - 2017

N2 - Context: An oligometastatic state is an early event during tumor metastatic spread and is rarely reported in patients with genitourinary tumors. In this condition, the primary tumor has low capacity for distal dissemination because its aggressiveness has not yet reached a maximum. Objective: To review recent findings on the diagnosis and treatment of oligometastatic disease in patients with genitourinary tumors. Evidence acquisition: To identify relevant studies, we reviewed articles in PubMed from January 1966 to September 2017. The search was conducted by combining the words "oligometastasis" or "oligometastatic disease" with "bladder cancer", "genitourinary tumor", "prostate cancer", and "renal cancer". Evidence synthesis: In renal cell carcinoma (RCC), tumors from patients with multiple metastases showed a different gene signature compared to oligometastatic RCC. In addition, an oligometastatic state was an independent prognostic factor for overall survival (OS). Otherwise, the characteristics of oligometastases from bladder cancer remain unclear, as do the clinical and prognostic significance of metastasectomy in this setting. However, patients with oligometastatic prostate cancer have longer recurrence-free survival and OS and seem to benefit from local metastasis-directed therapies. Conclusions: Early detection of oligometastatic disease in patients with genitourinary tumors is fundamental in improving outcomes by identifying patients who would benefit from local approaches with potentially curative rather than palliative intent. Patients with oligometastases in genitourinary tumors show longer survival because of generally lower tumor aggressiveness and potential eligibility for local approaches. Emerging molecular diagnostic techniques will allow early diagnosis of the oligometastatic state and consequently improve patient outcomes.

AB - Context: An oligometastatic state is an early event during tumor metastatic spread and is rarely reported in patients with genitourinary tumors. In this condition, the primary tumor has low capacity for distal dissemination because its aggressiveness has not yet reached a maximum. Objective: To review recent findings on the diagnosis and treatment of oligometastatic disease in patients with genitourinary tumors. Evidence acquisition: To identify relevant studies, we reviewed articles in PubMed from January 1966 to September 2017. The search was conducted by combining the words "oligometastasis" or "oligometastatic disease" with "bladder cancer", "genitourinary tumor", "prostate cancer", and "renal cancer". Evidence synthesis: In renal cell carcinoma (RCC), tumors from patients with multiple metastases showed a different gene signature compared to oligometastatic RCC. In addition, an oligometastatic state was an independent prognostic factor for overall survival (OS). Otherwise, the characteristics of oligometastases from bladder cancer remain unclear, as do the clinical and prognostic significance of metastasectomy in this setting. However, patients with oligometastatic prostate cancer have longer recurrence-free survival and OS and seem to benefit from local metastasis-directed therapies. Conclusions: Early detection of oligometastatic disease in patients with genitourinary tumors is fundamental in improving outcomes by identifying patients who would benefit from local approaches with potentially curative rather than palliative intent. Patients with oligometastases in genitourinary tumors show longer survival because of generally lower tumor aggressiveness and potential eligibility for local approaches. Emerging molecular diagnostic techniques will allow early diagnosis of the oligometastatic state and consequently improve patient outcomes.

KW - Bladder cancer

KW - Early diagnosis

KW - Genitourinary tumors

KW - Kidney cancer

KW - Oligometastasis

KW - Prostate cancer

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