On characterization of proteomics maps and chemically induced changes in proteomes using matrix invariants: Application to peroxisome proliferators

Milan Randić, Frank Witzmann, Marjan Vračko, Subhash C. Basak

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

In this paper we have reported a mathematical method for the compact characterization of proteomics maps. Selected spots from proteomics maps are transformed into 3-D curves which, in turn, are represented by D/D matrices. The leading eigenvalues of such matrices and their higher powers are used as biodescriptors to characterize proteomics patterns. The set of biodescriptors derived from the normal cells and cells exposed to four peroxisome proliferators show that these compact biodescriptors are able to discriminate the characteristic effects of these toxicants on the cellular proteome.

Original languageEnglish (US)
Pages (from-to)456-479
Number of pages24
JournalMedicinal Chemistry Research
Volume10
Issue number7-8
StatePublished - Dec 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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