On the importance of pedal edema in hemodialysis patients

Rajiv Agarwal, Martin J. Andersen, J. Howard Pratt

Research output: Contribution to journalArticle

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Abstract

Background and objectives: Volume control is a key component of treatment of hemodialysis patients. The role of pedal edema as a marker of volume is unknown. The objective of this study was to determine factors that are associated with edema. Design, setting, participants, & measurements: A cross-sectional study of asymptomatic hemodialysis patients (n = 146) in four university-affiliated hemodialysis units was conducted. Echocardiographic variables, blood volume monitoring, plasma volume markers (plasma renin and aldosterone and N-terminal pro B-type natriuretic peptide), and inflammation markers (C-reactive protein and IL-6) were measured as exposures, and edema was measured as outcome. Results: In a multivariate logistic regression analysis, age, body mass index, and left ventricular hypertrophy were independent determinants of edema. Compared with patients with normal or low weight, overweight patients had odds ratio for edema of 5.7 (95% confidence interval [CI] 1.0 to 31.8), and obese patients of 44.8 (95% CI 9.0 to 223). Patients in the top quartile of left ventricular mass index and normal to low weight had odds ratio of edema of 7.7 (95% CI 2.3-25.9), those who were overweight of 43.5 (95% CI 3.9 to 479.8), and those who were obese of 344.8 (95% Cl 33.8 to 3515). Inferior vena cava diameter, blood volume monitoring, plasma volume markers, and inflammation markers were not determinants of edema. Conclusions: Pedal edema correlates with cardiovascular risk factors such as age, body mass index, and left ventricular mass but does not reflect volume in hemodialysis patients.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalClinical Journal of the American Society of Nephrology
Volume3
Issue number1
DOIs
StatePublished - Jan 2008

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Renal Dialysis
Foot
Edema
Confidence Intervals
Plasma Volume
Blood Volume
Body Mass Index
Odds Ratio
Inflammation
Weights and Measures
Brain Natriuretic Peptide
Inferior Vena Cava
Left Ventricular Hypertrophy
Aldosterone
Renin
C-Reactive Protein
Interleukin-6
Cross-Sectional Studies
Logistic Models
Regression Analysis

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Medicine(all)

Cite this

On the importance of pedal edema in hemodialysis patients. / Agarwal, Rajiv; Andersen, Martin J.; Pratt, J. Howard.

In: Clinical Journal of the American Society of Nephrology, Vol. 3, No. 1, 01.2008, p. 153-158.

Research output: Contribution to journalArticle

Agarwal, Rajiv ; Andersen, Martin J. ; Pratt, J. Howard. / On the importance of pedal edema in hemodialysis patients. In: Clinical Journal of the American Society of Nephrology. 2008 ; Vol. 3, No. 1. pp. 153-158.
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