On the in vivo significance of bacterial resistance to antimicrobial peptides

Margaret E. Bauer, William M. Shafer

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Antimicrobial peptides (AMPs) are at the front-line of host defense during infection and play critical roles both in reducing the microbial load early during infection and in linking innate to adaptive immunity. However, successful pathogens have developed mechanisms to resist AMPs. Although considerable progress has been made in elucidating AMP-resistance mechanisms of pathogenic bacteria in vitro, less is known regarding the in vivo significance of such resistance. Nevertheless, progress has been made in this area, largely by using murine models and, in two instances, human models of infection. Herein, we review progress on the use of in vivo infection models in AMP research and discuss the AMP resistance mechanisms that have been established by in vivo studies to contribute to microbial infection. We posit that in vivo infection models are essential tools for investigators to understand the significance to pathogenesis of genetic changes that impact levels of bacterial susceptibility to AMPs. This article is part of a Special Issue entitled: Bacterial Resistance to Antimicrobial Peptides.

Original languageEnglish (US)
Article number81818
Pages (from-to)3101-3111
Number of pages11
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1848
Issue number11
DOIs
StatePublished - Feb 7 2015

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Keywords

  • Antimicrobial peptides
  • Cell envelope modifications
  • In vivo models
  • Pathogenesis
  • Resistance mechanisms
  • Transporters

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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