On the possible relationship of cortical microvascular pathology to blood brain barrier changes in Alzheimer's disease

Arnold B. Scheibel, Taihung Duong

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A group of alterations in the structure of cortical microvessels is described in the brain tissue of neuropathologically confirmed patients with Alzheimer's disease. These changes include irregular thickening of the vessel walls, infiltration with amyloid and the serum P component of amyloid, loss of the perivascular neural plexus and the frequent occurrence of pits and lacunae in vessel walls. The possibility that these alterations may be related to blood brain barrier defects is suggested.

Original languageEnglish (US)
Pages (from-to)41-42
Number of pages2
JournalNeurobiology of Aging
Volume9
Issue numberC
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Serum Amyloid P-Component
Microvessels
Blood-Brain Barrier
Amyloid
Alzheimer Disease
Pathology
Brain

ASJC Scopus subject areas

  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neuroscience(all)
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

On the possible relationship of cortical microvascular pathology to blood brain barrier changes in Alzheimer's disease. / Scheibel, Arnold B.; Duong, Taihung.

In: Neurobiology of Aging, Vol. 9, No. C, 1988, p. 41-42.

Research output: Contribution to journalArticle

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