Oncocytoma-like angiomyolipoma: A clinicopathologic and immunohistochemical study of 2 cases

Guido Martignoni, Maurizio Pea, Franco Bonetti, Matteo Brunelli, John N. Eble

Research output: Contribution to journalArticle

45 Scopus citations


We report the clinical, pathologic, and immunohistochemical features of an unusual tumor of the kidney composed of densely eosinophilic, polygonal epithelioid cells. The patients were a 56-year-old woman and a 35-year-old man. The renal tumors were discovered during follow-up for breast carcinoma and evaluation for abdominal pain, respectively. The tumors closely resembled oncocytoma in routine sections, but were negative for epithelial markers and positive for HMB-45, a pattern of reactions characteristic of angiomyolipoma. In the woman, a single additional microscopic angiomyolipoma was present in the renal parenchyma at a distance from the main tumor. Both patients are alive without recurrence 7 and 10 years after surgery, respectively. Based on clinical, morphologic, and immunophenotypic features, we conclude that these tumors are oncocytoma-like angiomyolipomas.

Original languageEnglish (US)
Pages (from-to)610-612
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Issue number5
StatePublished - May 18 2002
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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