Ondansetron in the treatment of cognitive decline in Alzheimer dementia

Maurice Dysken, Michael Kuskowski, Susan Love, Nathan Billig, Richard Borison, Rachelle Doody, David Drachman, Eugene DeBoff, David Dunner, Mildred Farmer, Sanford Finkel, Norman Foster, Arthur Freeman, Neill Graff-Radford, Robert Green, George Grossberg, Hugh Hendrie, William Jagust, Lawrence Jenkyn, John MorrisSheldon Preskorn, Mary Sano, Benjamin Seltzer, Paul Tuttle

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The authors performed a multicenter, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of ondansetron (20 μg/day and 100 μg/day) in treating cognitive decline in 185 patients with Alzheimer disease. Although ondansetron was well tolerated without any serious drug-related side effects, the study failed to demonstrate any significant cognitive improvement.

Original languageEnglish (US)
Pages (from-to)212-215
Number of pages4
JournalAmerican Journal of Geriatric Psychiatry
Volume10
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

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Ondansetron
Alzheimer Disease
Controlled Clinical Trials
Drug-Related Side Effects and Adverse Reactions
Placebos
Safety
Therapeutics
Cognitive Dysfunction

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

Cite this

Dysken, M., Kuskowski, M., Love, S., Billig, N., Borison, R., Doody, R., ... Tuttle, P. (2002). Ondansetron in the treatment of cognitive decline in Alzheimer dementia. American Journal of Geriatric Psychiatry, 10(2), 212-215. https://doi.org/10.1097/00019442-200203000-00013

Ondansetron in the treatment of cognitive decline in Alzheimer dementia. / Dysken, Maurice; Kuskowski, Michael; Love, Susan; Billig, Nathan; Borison, Richard; Doody, Rachelle; Drachman, David; DeBoff, Eugene; Dunner, David; Farmer, Mildred; Finkel, Sanford; Foster, Norman; Freeman, Arthur; Graff-Radford, Neill; Green, Robert; Grossberg, George; Hendrie, Hugh; Jagust, William; Jenkyn, Lawrence; Morris, John; Preskorn, Sheldon; Sano, Mary; Seltzer, Benjamin; Tuttle, Paul.

In: American Journal of Geriatric Psychiatry, Vol. 10, No. 2, 2002, p. 212-215.

Research output: Contribution to journalArticle

Dysken, M, Kuskowski, M, Love, S, Billig, N, Borison, R, Doody, R, Drachman, D, DeBoff, E, Dunner, D, Farmer, M, Finkel, S, Foster, N, Freeman, A, Graff-Radford, N, Green, R, Grossberg, G, Hendrie, H, Jagust, W, Jenkyn, L, Morris, J, Preskorn, S, Sano, M, Seltzer, B & Tuttle, P 2002, 'Ondansetron in the treatment of cognitive decline in Alzheimer dementia', American Journal of Geriatric Psychiatry, vol. 10, no. 2, pp. 212-215. https://doi.org/10.1097/00019442-200203000-00013
Dysken, Maurice ; Kuskowski, Michael ; Love, Susan ; Billig, Nathan ; Borison, Richard ; Doody, Rachelle ; Drachman, David ; DeBoff, Eugene ; Dunner, David ; Farmer, Mildred ; Finkel, Sanford ; Foster, Norman ; Freeman, Arthur ; Graff-Radford, Neill ; Green, Robert ; Grossberg, George ; Hendrie, Hugh ; Jagust, William ; Jenkyn, Lawrence ; Morris, John ; Preskorn, Sheldon ; Sano, Mary ; Seltzer, Benjamin ; Tuttle, Paul. / Ondansetron in the treatment of cognitive decline in Alzheimer dementia. In: American Journal of Geriatric Psychiatry. 2002 ; Vol. 10, No. 2. pp. 212-215.
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