One Size Fits One

Pharmacogenetics in Gastroenterology

Prashanth Porayette, David Flockhart, Sandeep Gupta

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Individual variability in response and development of adverse effects to drugs is a major challenge in clinical practice. Pharmacogenomics refers to the aspect of personalized medicine where the patient's genetic information instructs the selection and dosage of therapy while also predicting its adverse effects profile. Sequencing of the entire human genome has given us the opportunity to study commonly used drugs as well as newer therapeutic agents in a new light, opening up opportunities for better drug efficacy and decreased adverse effects. This article highlights developments in pharmacogenomics, relates these to practice of gastroenterology, and outlines roadblocks in translation of this knowledge into clinical practice.

Original languageEnglish
Pages (from-to)565-570
Number of pages6
JournalClinical Gastroenterology and Hepatology
Volume12
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Pharmacogenetics
Gastroenterology
Pharmaceutical Preparations
Precision Medicine
Translational Medical Research
Human Genome
Therapeutics

Keywords

  • Gastroenterology
  • Personalized medicine
  • Pharmacogenetics

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

One Size Fits One : Pharmacogenetics in Gastroenterology. / Porayette, Prashanth; Flockhart, David; Gupta, Sandeep.

In: Clinical Gastroenterology and Hepatology, Vol. 12, No. 4, 2014, p. 565-570.

Research output: Contribution to journalArticle

Porayette, Prashanth ; Flockhart, David ; Gupta, Sandeep. / One Size Fits One : Pharmacogenetics in Gastroenterology. In: Clinical Gastroenterology and Hepatology. 2014 ; Vol. 12, No. 4. pp. 565-570.
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