One Size Fits One: Pharmacogenetics in Gastroenterology

Prashanth Porayette, David Flockhart, Sandeep K. Gupta

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Individual variability in response and development of adverse effects to drugs is a major challenge in clinical practice. Pharmacogenomics refers to the aspect of personalized medicine where the patient's genetic information instructs the selection and dosage of therapy while also predicting its adverse effects profile. Sequencing of the entire human genome has given us the opportunity to study commonly used drugs as well as newer therapeutic agents in a new light, opening up opportunities for better drug efficacy and decreased adverse effects. This article highlights developments in pharmacogenomics, relates these to practice of gastroenterology, and outlines roadblocks in translation of this knowledge into clinical practice.

Original languageEnglish (US)
Pages (from-to)565-570
Number of pages6
JournalClinical Gastroenterology and Hepatology
Volume12
Issue number4
DOIs
StatePublished - Apr 2014

Keywords

  • Gastroenterology
  • Personalized medicine
  • Pharmacogenetics

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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