Onset and progression of with-the-rule astigmatism in children with infantile nystagmus syndrome

Jingyun Wang, Lauren M. Wyatt, Joost Felius, David R. Stager, David R. Stager, Eileen E. Birch, Harold E. Bedell

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

PURPOSE. The purpose of this study was to examine the onset and progression of with-the-rule (WTR) astigmatism during the first 8 years of life in children with idiopathic infantile nystagmus syndrome (INS) or INS associated with albinism and to compare their development with that of normal children. Also explored was whether early WTR astigmatism influences emmetropization in children with INS and whether there is evidence of meridional emmetropization. METHODS. Cycloplegic refractions culled from medical records were converted into power vector components: M (spherical equivalent), J0 (positive J0 indicates WTR astigmatism), and J45 (oblique astigmatism). Two diagnostic groups (idiopathic, n = 106; albinism, n = 95) were evaluated and compared with a reference normal group (n = 495). Four age subgroups were evaluated: age≤0.5 year, 0.50 from the fitted longitudinal data agreed with crosssectional data. Moreover, the spherical equivalent of children with INS demonstrated little emmetropization during the first 8 years of life. CONCLUSIONS. Both the cross-sectional and longitudinal data showed that WTR astigmatism was common among children with INS and increased in magnitude with age during the first 8 years of life. Changes observed in meridional refractive error with age were consistent with meridional emmetropization in children with INS and WTR astigmatism.

Original languageEnglish (US)
Pages (from-to)594-601
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume51
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

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Astigmatism
Albinism
Mydriatics
Myeloma Proteins
Refractive Errors
Medical Records

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Wang, J., Wyatt, L. M., Felius, J., Stager, D. R., Stager, D. R., Birch, E. E., & Bedell, H. E. (2010). Onset and progression of with-the-rule astigmatism in children with infantile nystagmus syndrome. Investigative Ophthalmology and Visual Science, 51(1), 594-601. https://doi.org/10.1167/iovs.09-3599

Onset and progression of with-the-rule astigmatism in children with infantile nystagmus syndrome. / Wang, Jingyun; Wyatt, Lauren M.; Felius, Joost; Stager, David R.; Stager, David R.; Birch, Eileen E.; Bedell, Harold E.

In: Investigative Ophthalmology and Visual Science, Vol. 51, No. 1, 01.2010, p. 594-601.

Research output: Contribution to journalArticle

Wang, J, Wyatt, LM, Felius, J, Stager, DR, Stager, DR, Birch, EE & Bedell, HE 2010, 'Onset and progression of with-the-rule astigmatism in children with infantile nystagmus syndrome', Investigative Ophthalmology and Visual Science, vol. 51, no. 1, pp. 594-601. https://doi.org/10.1167/iovs.09-3599
Wang, Jingyun ; Wyatt, Lauren M. ; Felius, Joost ; Stager, David R. ; Stager, David R. ; Birch, Eileen E. ; Bedell, Harold E. / Onset and progression of with-the-rule astigmatism in children with infantile nystagmus syndrome. In: Investigative Ophthalmology and Visual Science. 2010 ; Vol. 51, No. 1. pp. 594-601.
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