Ontogeny of cardiac sympathetic innervation and its implications for cardiac disease

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The vertebrate heart is innervated by the sympathetic and parasympathetic components of the peripheral autonomic nervous system, which regulates its contractile rate and force. Understanding the mechanisms that control sympathetic neuronal growth, differentiation, and innervation of the heart may provide insight into the etiology of cardiac arrhythmogenesis. This review provides an overview of the cell signaling pathways and transcriptional effectors that regulate both the noradrenergic gene program during sympathetic neurogenesis and regional nerve density during cardiac innervation. Recent studies exploring transcriptional regulation of the bHLH transcription factor Hand1 in developing sympathetic neurons are explored, and how the Hand1 sympathetic neuron-specific cis-regulatory element may be used further to assess the contribution of altered sympathetic innervation to human cardiac disease is discussed.

Original languageEnglish
Pages (from-to)923-928
Number of pages6
JournalPediatric Cardiology
Volume33
Issue number6
DOIs
StatePublished - Aug 2012

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Heart Diseases
Basic Helix-Loop-Helix Transcription Factors
Neurons
Autonomic Nervous System
Neurogenesis
Peripheral Nervous System
Vertebrates
Growth
Genes

Keywords

  • Cardiac arrhythmogenesis
  • Cardiac innervation
  • Hand1
  • Sympathetic neurogenesis
  • Vertebrate heart

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Ontogeny of cardiac sympathetic innervation and its implications for cardiac disease. / Vincentz, Joshua W.; Rubart-von der Lohe, Michael; Firulli, Anthony.

In: Pediatric Cardiology, Vol. 33, No. 6, 08.2012, p. 923-928.

Research output: Contribution to journalArticle

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