Operant responding for oral ethanol in the alcohol-preferring P and alcohol-nonpreferring NP lines of rats

J. M. Murphy, G. J. Gatto, W. J. McBride, L. Lumeng, T. K. Li

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Rats of the P (n=4) and NP (n=5) lines were housed in operant chambers with food available ad lib, but all liquid was obtained by responding on either of two levers according to a FR5 schedule. Presses on one lever produced water from an automated dipper, while the other lever gave access to a dipper containing ethanol in concentrations ranging from 2 to 30% (v/v). P rats worked to obtain the ethanol at all concentrations offered and preferred the ethanol over water. The highest ethanol intake averaged 7.7±0.5 g/kg body weight/day at the 15% concentration and at least 5.8±0.9 g/kg/day for the 20-30% range. The NP rats responded more for the 2 and 5% concentrations of ethanol than for water, but responded predominately for water when the ethanol concentrations were 10% and higher. In a second experiment, NP rats drank water rather than 10% ethanol by free-choice, even though the ethanol was mixed with a preferred flavor and the water with a nonpreferred flavor. The findings indicate that ethanol is rewarding to P rats in concentrations up to 30% (v/v) but is not rewarding to NP rats when the concentration is 10% and above.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalAlcohol
Volume6
Issue number2
DOIs
StatePublished - 1989

Fingerprint

Rats
Ethanol
alcohol
Alcohols
water
Water
Flavors
body weight
chamber
food
experiment
Appointments and Schedules
Body Weight
Food
Liquids

Keywords

  • Alcohol drinking behavior
  • Alcohol-nonpreferring rats
  • Alcohol-preferring rats
  • Ethanol reinforcement
  • Operant behavior

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Neuroscience(all)
  • Behavioral Neuroscience
  • Toxicology
  • Health(social science)

Cite this

Operant responding for oral ethanol in the alcohol-preferring P and alcohol-nonpreferring NP lines of rats. / Murphy, J. M.; Gatto, G. J.; McBride, W. J.; Lumeng, L.; Li, T. K.

In: Alcohol, Vol. 6, No. 2, 1989, p. 127-131.

Research output: Contribution to journalArticle

Murphy, J. M. ; Gatto, G. J. ; McBride, W. J. ; Lumeng, L. ; Li, T. K. / Operant responding for oral ethanol in the alcohol-preferring P and alcohol-nonpreferring NP lines of rats. In: Alcohol. 1989 ; Vol. 6, No. 2. pp. 127-131.
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