Operant response suppression induced with systemic administration of 5-hydroxytryptophan is centrally mediated

Eric A. Engleman, James M. Murphy, Feng C. Zhou, Morris H. Aprison, Joseph N. Hingtgen

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Intracerebroventricular (ICV) administration of selective serotonergic agents was used to examine the extent of central mediation of 5-HTP-induced operant response suppression in rats. ICV administration of LY53857 (1.0, 3.75, or 7.5 μg/5 μl/5 min) dose dependently blocked response suppression induced with systemically administered 5-HTP (25 mg/kg, IP), whereas ICV 0.9% saline (5 μl over 5 min) had no significant effect on 5-HTP-induced response suppression. ICV ketanserin (7.5 μg/5 μl/5 min) also blocked response suppression induced with systemically administered 5-HTP. ICV administration of the 5-HT 2A 2C receptor agonist DOI (80 μg/5 μl/5 min) induced significant periods of response suppression in this model, which was blocked with LY53857 (1.0 mg/kg, IP) pretreatment. These data demonstrate that central administration of 5-HT 2A 2C antagonists potently attenuate operant response suppression induced with systemically administered 5-HTP or DOI and are in agreement with previous findings suggesting central mediation of 5-HTP-induced operant response suppression.

Original languageEnglish (US)
Pages (from-to)525-529
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume52
Issue number3
DOIs
StatePublished - Nov 1995

Keywords

  • 5-HT receptors
  • 5-Hydroxytryptophan
  • Behavior
  • Depression Intracerebroventricular administration
  • Operant conditioning
  • Operant responding
  • Rats
  • Serotonin
  • Serotonin agonists
  • Serotonin antagonists

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Pharmacology
  • Toxicology

Fingerprint Dive into the research topics of 'Operant response suppression induced with systemic administration of 5-hydroxytryptophan is centrally mediated'. Together they form a unique fingerprint.

  • Cite this