Ophthalmic arterial hemodynamics during isometric exercise

Dennis Beck, Alon Harris, David Evans, Bruce Martin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: Isometric exercise raises systemic arterial pressure and simultaneously lowers intraocular pressure. Together, these pressor effects increase calculated ocular perfusion pressure and test the capacity for flow and pressure autoregulation in the orbital circulation. Methods: We investigated in 17 young, healthy subjects the effect of isometric exercise on ophthalmic arterial hemodynamics, as measured by color Dopp-ler imaging. Isometric handgrip was maintained for 10 min at 20% maximal force. Results: Handgrip predictably raised systolic (114 ± 2 to 122 ± 3 mm Hg; p < 0.01), diastolic (69 ± 2 to 78 ± 2 mm Hg; p < 0.01), and mean systemic pressures (84 ± 2 to 93 ± 3 mm Hg; p < 0.01). Because exercise also reduced intraocular pressure (from 14.2 ±.5 to 12.2 ±.4 mm Hg, p < 0.01), calculated ocular perfusion pressure increased from 42 ± 3 mm Hg before exericse to 50 ± 3 mm Hg during exercise (p < 0.01). Despite this pressure increase, we found no evidence for exercise-induced vasoconstriction in the ophthalmic artery: peak systolic velocity (PSV) was unaltered by exercise, whereas end-diastolic velocity (EDV) increased (from 5.8 ±.5 mm/s at rest to 8.4 ± 1.3 mm/s during exercise; p < 0.01). These velocity changes reduced the calculated resistance index ((PSV - EDV)/PSV) from 0.82 ± 0.01 at rest to 0.78 ± 0.02 during exercise (p < 0.05). Conclusion: Isometric exercise-induced increases in ocular perfusion pressure are apparently associated with reductions in vascular resistance distal to the ophthalmic artery, a result suggesting that ocular blood flow or microvas-cular pressures may be autoregulated by vascular adjustment proximal to the orbit itself.

Original languageEnglish (US)
Pages (from-to)317-321
Number of pages5
JournalJournal of Glaucoma
Volume4
Issue number5
StatePublished - Oct 1995

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Hemodynamics
Exercise
Pressure
Ophthalmic Artery
Perfusion
Intraocular Pressure
Orbit
Vasoconstriction
Vascular Resistance
Blood Vessels
Healthy Volunteers
Arterial Pressure
Homeostasis
Color

Keywords

  • Isometric exercise
  • Ophthalmic arterial hemodynamics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Beck, D., Harris, A., Evans, D., & Martin, B. (1995). Ophthalmic arterial hemodynamics during isometric exercise. Journal of Glaucoma, 4(5), 317-321.

Ophthalmic arterial hemodynamics during isometric exercise. / Beck, Dennis; Harris, Alon; Evans, David; Martin, Bruce.

In: Journal of Glaucoma, Vol. 4, No. 5, 10.1995, p. 317-321.

Research output: Contribution to journalArticle

Beck, D, Harris, A, Evans, D & Martin, B 1995, 'Ophthalmic arterial hemodynamics during isometric exercise', Journal of Glaucoma, vol. 4, no. 5, pp. 317-321.
Beck, Dennis ; Harris, Alon ; Evans, David ; Martin, Bruce. / Ophthalmic arterial hemodynamics during isometric exercise. In: Journal of Glaucoma. 1995 ; Vol. 4, No. 5. pp. 317-321.
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AB - Purpose: Isometric exercise raises systemic arterial pressure and simultaneously lowers intraocular pressure. Together, these pressor effects increase calculated ocular perfusion pressure and test the capacity for flow and pressure autoregulation in the orbital circulation. Methods: We investigated in 17 young, healthy subjects the effect of isometric exercise on ophthalmic arterial hemodynamics, as measured by color Dopp-ler imaging. Isometric handgrip was maintained for 10 min at 20% maximal force. Results: Handgrip predictably raised systolic (114 ± 2 to 122 ± 3 mm Hg; p < 0.01), diastolic (69 ± 2 to 78 ± 2 mm Hg; p < 0.01), and mean systemic pressures (84 ± 2 to 93 ± 3 mm Hg; p < 0.01). Because exercise also reduced intraocular pressure (from 14.2 ±.5 to 12.2 ±.4 mm Hg, p < 0.01), calculated ocular perfusion pressure increased from 42 ± 3 mm Hg before exericse to 50 ± 3 mm Hg during exercise (p < 0.01). Despite this pressure increase, we found no evidence for exercise-induced vasoconstriction in the ophthalmic artery: peak systolic velocity (PSV) was unaltered by exercise, whereas end-diastolic velocity (EDV) increased (from 5.8 ±.5 mm/s at rest to 8.4 ± 1.3 mm/s during exercise; p < 0.01). These velocity changes reduced the calculated resistance index ((PSV - EDV)/PSV) from 0.82 ± 0.01 at rest to 0.78 ± 0.02 during exercise (p < 0.05). Conclusion: Isometric exercise-induced increases in ocular perfusion pressure are apparently associated with reductions in vascular resistance distal to the ophthalmic artery, a result suggesting that ocular blood flow or microvas-cular pressures may be autoregulated by vascular adjustment proximal to the orbit itself.

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