Opioid dose and risk of suicide

Mark A. Ilgen, Amy S B Bohnert, Dara Ganoczy, Matthew Bair, John F. Mccarthy, Frederic C. Blow

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Chronic pain is associated with increased risk of suicide, and opioids are commonly used to treat moderate to severe pain. However, the association between opioid dose and suicide mortality has not been examined closely. This retrospective data analysis described the risk of suicide associated with differing prescribed opioid doses. Data were from Veterans Affairs health care system treatment records and the National Death Index. Records analyzed were those of Veterans Affairs patients with chronic pain receiving opioids in fiscal years 2004 to 2005 (N 123,946). Primary predictors were maximum prescribed morphine-equivalent daily opioid dose and opioid fill type. The main outcome measured was suicide death, by any mechanism, and intentional overdose death during 2004 to 2009. Controlling for demographic and clinical characteristics, higher prescribed opioid doses were associated with elevated suicide risk. Compared with those receiving ≤20 milligrams/day (mg/d), hazard ratios were 1.48 (95% confidence intervals [CI], 1.25-1.75) for 20 to

Original languageEnglish (US)
Pages (from-to)1079-1084
Number of pages6
JournalPain
Volume157
Issue number5
DOIs
StatePublished - May 1 2016

Fingerprint

Suicide
Opioid Analgesics
Chronic Pain
Veterans Health
Death Certificates
Veterans
Morphine
Demography
Confidence Intervals
Delivery of Health Care
Pain
Mortality

Keywords

  • Opioids
  • Overdose
  • Suicide

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine
  • Neurology
  • Pharmacology

Cite this

Ilgen, M. A., Bohnert, A. S. B., Ganoczy, D., Bair, M., Mccarthy, J. F., & Blow, F. C. (2016). Opioid dose and risk of suicide. Pain, 157(5), 1079-1084. https://doi.org/10.1097/j.pain.0000000000000484

Opioid dose and risk of suicide. / Ilgen, Mark A.; Bohnert, Amy S B; Ganoczy, Dara; Bair, Matthew; Mccarthy, John F.; Blow, Frederic C.

In: Pain, Vol. 157, No. 5, 01.05.2016, p. 1079-1084.

Research output: Contribution to journalArticle

Ilgen, MA, Bohnert, ASB, Ganoczy, D, Bair, M, Mccarthy, JF & Blow, FC 2016, 'Opioid dose and risk of suicide', Pain, vol. 157, no. 5, pp. 1079-1084. https://doi.org/10.1097/j.pain.0000000000000484
Ilgen MA, Bohnert ASB, Ganoczy D, Bair M, Mccarthy JF, Blow FC. Opioid dose and risk of suicide. Pain. 2016 May 1;157(5):1079-1084. https://doi.org/10.1097/j.pain.0000000000000484
Ilgen, Mark A. ; Bohnert, Amy S B ; Ganoczy, Dara ; Bair, Matthew ; Mccarthy, John F. ; Blow, Frederic C. / Opioid dose and risk of suicide. In: Pain. 2016 ; Vol. 157, No. 5. pp. 1079-1084.
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