Opioid involvement in alcohol drinking

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

A large body of evidence indicates that the endogenous opioid system plays an important role in maintaining alcohol drinking behavior. Evidence is reviewed that indicates that the reinforcing properties of alcohol that lead to continued and repeated bouts of drinking may be due, in part, to alcohol-induced activation of the endogenous opioid system. Much of this evidence is pharmacologic in nature. Blocking the action of endogenous opioid peptides via administration of opioid antagonists significantly attenuates alcohol consumption in animals under a variety of experimental conditions. In clinical trials, opioid receptor antagonists decrease alcohol consumption, relapse rates, subjective high, and alcohol craving in outpatient alcoholics. The potential clinical utility of opioid receptor antagonists in the treatment of alcoholism and alcohol dependence is discussed.

Original languageEnglish
Pages (from-to)156-167
Number of pages12
JournalAnnals of the New York Academy of Sciences
Volume739
StatePublished - 1994

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Narcotic Antagonists
Alcohol Drinking
Opioid Analgesics
Alcohols
Alcoholism
Drinking Behavior
Opioid Peptides
Alcoholics
Drinking
Outpatients
Clinical Trials
Recurrence
Alcohol
Animals
Chemical activation
Therapeutics
Antagonist

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Opioid involvement in alcohol drinking. / Froehlich, Janice; Li, T. K.

In: Annals of the New York Academy of Sciences, Vol. 739, 1994, p. 156-167.

Research output: Contribution to journalArticle

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