OPO Strategies to Prevent Unintended Use of Kidneys Exported for High PRA (>98% cPRA) Recipients

A. S. Paramesh, N. Neidlinger, M. Salvatore, A. Smith, A. Friedman, W. Payne, Tim Taber, C. Wright

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Since the advent of the Kidney Allocation System (KAS), matched candidates with high (>98%) panel reactive antibody (hPRA) are given priority over local candidates with lower PRA. This often leads to exporting of kidneys. Data for these kidneys are not detailed on routine reports. Twenty-two organ procurement organizations prospectively submitted data from August 2015 to July 2016, describing allocation practices of kidneys to hPRA patients and outcomes of these kidneys. Five hundred twenty out of 6924 procured kidneys were exported for hPRA recipients. Of these, 402 (77.3%) were transplanted into the intended recipient (IR); 100 (19.2%) were transplanted into unintended recipients (UR), and 18 (3.5%) were discarded. The most common reason for use in an UR was a positive crossmatch (XM) (63%). The most common reasons for discard were donor quality (44%) and ischemic time (39%). Prior to kidney export, when tissue crossmatching was done, 96.2% of the kidneys went to the IR, versus 80.7% following virtual CM, versus 56.7% when no crossmatching was performed (p < 0.0001). A significant number of kidneys exported for hPRA patients are not being used in the IR or are being discarded. The most common reason for this is positive tissue XM. We report that unintended use of the kidney was minimized when tissue was shipped and XM results were known prior to exporting the kidney.

Original languageEnglish (US)
JournalAmerican Journal of Transplantation
DOIs
StateAccepted/In press - 2017

Fingerprint

Kidney
Histocompatibility Testing
Tissue and Organ Procurement
Tissue Donors
Antibodies

Keywords

  • Alloantibody
  • Clinical research/practice
  • Crossmatch
  • Health services and outcomes research
  • Histocompatibility
  • Kidney transplantation/nephrology
  • Organ allocation
  • Organ procurement and allocation
  • Organ procurement organization
  • Panel reactive antibody (PRA)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Paramesh, A. S., Neidlinger, N., Salvatore, M., Smith, A., Friedman, A., Payne, W., ... Wright, C. (Accepted/In press). OPO Strategies to Prevent Unintended Use of Kidneys Exported for High PRA (>98% cPRA) Recipients. American Journal of Transplantation. https://doi.org/10.1111/ajt.14220

OPO Strategies to Prevent Unintended Use of Kidneys Exported for High PRA (>98% cPRA) Recipients. / Paramesh, A. S.; Neidlinger, N.; Salvatore, M.; Smith, A.; Friedman, A.; Payne, W.; Taber, Tim; Wright, C.

In: American Journal of Transplantation, 2017.

Research output: Contribution to journalArticle

Paramesh, A. S. ; Neidlinger, N. ; Salvatore, M. ; Smith, A. ; Friedman, A. ; Payne, W. ; Taber, Tim ; Wright, C. / OPO Strategies to Prevent Unintended Use of Kidneys Exported for High PRA (>98% cPRA) Recipients. In: American Journal of Transplantation. 2017.
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