Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network

Kenneth D. Levy, Kathryn Blake, Colette Fletcher-Hoppe, James Franciosi, Diasuke Goto, James K. Hicks, Ann M. Holmes, Sri Harsha Kanuri, Ebony B. Madden, Michael D. Musty, Lori Orlando, Victoria M. Pratt, Michelle Ramos, Ryanne Wu, Geoffrey S. Ginsburg

Research output: Contribution to journalArticle

4 Scopus citations


Purpose: While there is growing scientific evidence for and significant advances in the use of genomic technologies in medicine, there is a significant lag in the clinical adoption and sustainability of genomic medicine. Here we describe the findings from the National Human Genome Research Institute’s (NHGRI) Implementing GeNomics In pracTicE (IGNITE) Network in identifying key constructs, opportunities, and challenges associated with driving sustainability of genomic medicine in clinical practice. Methods: Network members and affiliates were surveyed to identify key drivers associated with implementing and sustaining a genomic medicine program. Tallied results were used to develop and weigh key constructs/drivers required to support sustainability of genomic medicine programs. Results: The top three driver–stakeholder dyads were (1) genomic training for providers, (2) genomic clinical decision support (CDS) tools embedded in the electronic health record (EHR), and (3) third party reimbursement for genomic testing. Conclusion: Priorities may differ depending on healthcare systems when comparing the current state of key drivers versus projected needs for supporting genomic medicine sustainability. Thus we provide gap-filling guidance based on IGNITE members’ experiences. Although results are limited to findings from the IGNITE network, their implementation, scientific, and clinical experience may be used as a road map by others considering implementing genomic medicine programs.

Original languageEnglish (US)
Pages (from-to)743-747
Number of pages5
JournalGenetics in Medicine
Issue number3
StatePublished - Mar 1 2019



  • Genomic education
  • Genomics
  • IGNITE Network
  • Implementation science
  • Sustainability

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Levy, K. D., Blake, K., Fletcher-Hoppe, C., Franciosi, J., Goto, D., Hicks, J. K., Holmes, A. M., Kanuri, S. H., Madden, E. B., Musty, M. D., Orlando, L., Pratt, V. M., Ramos, M., Wu, R., & Ginsburg, G. S. (2019). Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network. Genetics in Medicine, 21(3), 743-747. https://doi.org/10.1038/s41436-018-0080-y