Opposite effects of insulin-like molecules and leptin in coronary heart disease of type 2 diabetes. Preliminary data

Johannes B. Ruige, Ilse Mertens, Robert Considine, Bernard P. Paelinck, Luc F. Van Gaal

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction: Leptin and insulin have been reported to be risk factors for coronary heart disease (CHD) in the general population, but their role in type 2 diabetes still remains unclear. Materials and methods: The role of leptin and insulin upon CHD in type 2 diabetes was assessed in 154 patients, aged 31-77 years, who were treated with oral anti-diabetic agents. Multivariate logistic regression analyses were used with CHD (an established history of CHD or an abnormal treadmill test) as dependent, and leptin, insulin and potential confounders as independent variables. Results: Endogenous insulin was significantly associated with CHD in a model controlling for gender, age, duration of diabetes, body mass index, smoking and leptin (Odds ratio 1.45 per decile, 95% confidence interval 1.11-1.90). Improving control for confounding by replacing body mass index by subcutaneous fat (CT-measured at the L4-L5 level) and height in this model, resulted in a significant negative association between leptin and CHD (OR 0.60, 95% CI 0.37-0.96). Discussion: Leptin might have a beneficial effect on CHD in type 2 diabetes, probably by counteracting the effect of insulin-like molecules or insulin resistance. The effect was elucidated only after careful control for confounding by subcutaneous fat, the main source of leptin production.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalInternational Journal of Cardiology
Volume111
Issue number1
DOIs
StatePublished - Jul 28 2006

Fingerprint

Leptin
Type 2 Diabetes Mellitus
Coronary Disease
Insulin
Subcutaneous Fat
Body Mass Index
Exercise Test
Insulin Resistance
Logistic Models
Smoking
Odds Ratio
Regression Analysis
Confidence Intervals
Population

Keywords

  • Coronary heart disease
  • Diabetes mellitus
  • Epidemiology
  • Insulin
  • Leptin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Opposite effects of insulin-like molecules and leptin in coronary heart disease of type 2 diabetes. Preliminary data. / Ruige, Johannes B.; Mertens, Ilse; Considine, Robert; Paelinck, Bernard P.; Van Gaal, Luc F.

In: International Journal of Cardiology, Vol. 111, No. 1, 28.07.2006, p. 19-25.

Research output: Contribution to journalArticle

Ruige, Johannes B. ; Mertens, Ilse ; Considine, Robert ; Paelinck, Bernard P. ; Van Gaal, Luc F. / Opposite effects of insulin-like molecules and leptin in coronary heart disease of type 2 diabetes. Preliminary data. In: International Journal of Cardiology. 2006 ; Vol. 111, No. 1. pp. 19-25.
@article{3ae25a31e87640b192f5ef76937bf115,
title = "Opposite effects of insulin-like molecules and leptin in coronary heart disease of type 2 diabetes. Preliminary data",
abstract = "Introduction: Leptin and insulin have been reported to be risk factors for coronary heart disease (CHD) in the general population, but their role in type 2 diabetes still remains unclear. Materials and methods: The role of leptin and insulin upon CHD in type 2 diabetes was assessed in 154 patients, aged 31-77 years, who were treated with oral anti-diabetic agents. Multivariate logistic regression analyses were used with CHD (an established history of CHD or an abnormal treadmill test) as dependent, and leptin, insulin and potential confounders as independent variables. Results: Endogenous insulin was significantly associated with CHD in a model controlling for gender, age, duration of diabetes, body mass index, smoking and leptin (Odds ratio 1.45 per decile, 95{\%} confidence interval 1.11-1.90). Improving control for confounding by replacing body mass index by subcutaneous fat (CT-measured at the L4-L5 level) and height in this model, resulted in a significant negative association between leptin and CHD (OR 0.60, 95{\%} CI 0.37-0.96). Discussion: Leptin might have a beneficial effect on CHD in type 2 diabetes, probably by counteracting the effect of insulin-like molecules or insulin resistance. The effect was elucidated only after careful control for confounding by subcutaneous fat, the main source of leptin production.",
keywords = "Coronary heart disease, Diabetes mellitus, Epidemiology, Insulin, Leptin",
author = "Ruige, {Johannes B.} and Ilse Mertens and Robert Considine and Paelinck, {Bernard P.} and {Van Gaal}, {Luc F.}",
year = "2006",
month = "7",
day = "28",
doi = "10.1016/j.ijcard.2005.06.042",
language = "English",
volume = "111",
pages = "19--25",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Opposite effects of insulin-like molecules and leptin in coronary heart disease of type 2 diabetes. Preliminary data

AU - Ruige, Johannes B.

AU - Mertens, Ilse

AU - Considine, Robert

AU - Paelinck, Bernard P.

AU - Van Gaal, Luc F.

PY - 2006/7/28

Y1 - 2006/7/28

N2 - Introduction: Leptin and insulin have been reported to be risk factors for coronary heart disease (CHD) in the general population, but their role in type 2 diabetes still remains unclear. Materials and methods: The role of leptin and insulin upon CHD in type 2 diabetes was assessed in 154 patients, aged 31-77 years, who were treated with oral anti-diabetic agents. Multivariate logistic regression analyses were used with CHD (an established history of CHD or an abnormal treadmill test) as dependent, and leptin, insulin and potential confounders as independent variables. Results: Endogenous insulin was significantly associated with CHD in a model controlling for gender, age, duration of diabetes, body mass index, smoking and leptin (Odds ratio 1.45 per decile, 95% confidence interval 1.11-1.90). Improving control for confounding by replacing body mass index by subcutaneous fat (CT-measured at the L4-L5 level) and height in this model, resulted in a significant negative association between leptin and CHD (OR 0.60, 95% CI 0.37-0.96). Discussion: Leptin might have a beneficial effect on CHD in type 2 diabetes, probably by counteracting the effect of insulin-like molecules or insulin resistance. The effect was elucidated only after careful control for confounding by subcutaneous fat, the main source of leptin production.

AB - Introduction: Leptin and insulin have been reported to be risk factors for coronary heart disease (CHD) in the general population, but their role in type 2 diabetes still remains unclear. Materials and methods: The role of leptin and insulin upon CHD in type 2 diabetes was assessed in 154 patients, aged 31-77 years, who were treated with oral anti-diabetic agents. Multivariate logistic regression analyses were used with CHD (an established history of CHD or an abnormal treadmill test) as dependent, and leptin, insulin and potential confounders as independent variables. Results: Endogenous insulin was significantly associated with CHD in a model controlling for gender, age, duration of diabetes, body mass index, smoking and leptin (Odds ratio 1.45 per decile, 95% confidence interval 1.11-1.90). Improving control for confounding by replacing body mass index by subcutaneous fat (CT-measured at the L4-L5 level) and height in this model, resulted in a significant negative association between leptin and CHD (OR 0.60, 95% CI 0.37-0.96). Discussion: Leptin might have a beneficial effect on CHD in type 2 diabetes, probably by counteracting the effect of insulin-like molecules or insulin resistance. The effect was elucidated only after careful control for confounding by subcutaneous fat, the main source of leptin production.

KW - Coronary heart disease

KW - Diabetes mellitus

KW - Epidemiology

KW - Insulin

KW - Leptin

UR - http://www.scopus.com/inward/record.url?scp=33746289628&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746289628&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2005.06.042

DO - 10.1016/j.ijcard.2005.06.042

M3 - Article

C2 - 16038995

AN - SCOPUS:33746289628

VL - 111

SP - 19

EP - 25

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 1

ER -