Optic disc haemorrhage and primary open-angle glaucoma: A clinical review

Uma Jasty, Alon Harris, Brent Siesky, Lucas W. Rowe, Alice C. Verticchio Vercellin, Sunu Mathew, Louis R. Pasquale

Research output: Contribution to journalReview article

Abstract

Studies have confirmed that optic disc haemorrhage (ODH) is a significant risk factor for the development and progression of primary open-angle glaucoma (POAG). Various populations have differing risk factors for developing POAG. As such, a literature review was conducted examining seven studies published in India, China, Japan, Australia, Korea and the USA. The goal of this review was to better identify ODH risk factors and their relationship to development and progression of POAG. Ultimately, patients with ODH have a greater risk for developing POAG across all populations analysed in this review. However, some populations demonstrated additional risk factors for ODH, such as increasing age and female gender. Paradoxically, data from several studies show that people of African descent have a reduced risk of ODH despite having increased risk of open-angle glaucoma than their Caucasian counterparts. By parsing out the complex relations between ODH and open-angle glaucoma stratified by age, gender and race, we may gain a broader understanding of glaucoma pathogenesis and derive individualised treatment strategies.

Original languageEnglish (US)
Article number314583
JournalBritish Journal of Ophthalmology
DOIs
StateAccepted/In press - Jan 1 2020
Externally publishedYes

Keywords

  • glaucoma
  • optic nerve
  • retina

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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    Jasty, U., Harris, A., Siesky, B., Rowe, L. W., Verticchio Vercellin, A. C., Mathew, S., & Pasquale, L. R. (Accepted/In press). Optic disc haemorrhage and primary open-angle glaucoma: A clinical review. British Journal of Ophthalmology, [314583]. https://doi.org/10.1136/bjophthalmol-2019-314583