Optic nerve head morphology in glaucoma patients of African descent is strongly correlated to retinal blood flow

Priyanka Kanakamedala, Alon Harris, Brent Siesky, Ariel Tyring, Michael Muchnik, George Eckert, Leslie Abrams Tobe

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Abstract

Background/Aims: To examine the relationship between change in optic nerve head (ONH) morphology and retinal blood flow in patients with open-angle glaucoma (OAG) of African (AD) and European descent (ED) over 3 years. Methods: 112 patients with OAG (29 AD; 83 ED) underwent assessment of ONH morphology using Heidelberg retinal tomography (HRT-III), and retinal blood flow using confocal scanning laser Doppler. Repeated-measures analysis of covariance was used to compare baseline and 3-year measurements, and Pearson correlations were calculated to evaluate the relationships. Results: In OAG patients of AD, change in superior mean retinal blood flow was strongly, negatively correlated with change in cup/disc (C/D) area ratio (r= -0.78, p=0.020) and cup area (r=-0.75, p=0.0283) and strongly, positively correlated with change in rim area (r=0.74, p=0.0328) over 3 years. In OAG patients of AD, change in inferior mean retinal blood flow was strongly, negatively correlated with changes in C/D area ratio (r=-0.88, p=0.0156) and linear C/D ratio (r= -0.86, p=0.0265) over 3 years. In OAG patients of ED, these correlations were weak and did not reach statistical significance. Discussion: OAG patients of AD may have a stronger vascular component to their glaucoma pathophysiology than patients of ED.

Original languageEnglish
Pages (from-to)1551-1554
Number of pages4
JournalBritish Journal of Ophthalmology
Volume98
Issue number11
DOIs
StatePublished - Nov 1 2014

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Optic Disk
Open Angle Glaucoma
Glaucoma
Blood Vessels
Lasers
Tomography

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

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Optic nerve head morphology in glaucoma patients of African descent is strongly correlated to retinal blood flow. / Kanakamedala, Priyanka; Harris, Alon; Siesky, Brent; Tyring, Ariel; Muchnik, Michael; Eckert, George; Tobe, Leslie Abrams.

In: British Journal of Ophthalmology, Vol. 98, No. 11, 01.11.2014, p. 1551-1554.

Research output: Contribution to journalArticle

Kanakamedala, Priyanka ; Harris, Alon ; Siesky, Brent ; Tyring, Ariel ; Muchnik, Michael ; Eckert, George ; Tobe, Leslie Abrams. / Optic nerve head morphology in glaucoma patients of African descent is strongly correlated to retinal blood flow. In: British Journal of Ophthalmology. 2014 ; Vol. 98, No. 11. pp. 1551-1554.
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