Optic nerve head (ONH) topographic analysis by stratus OCT in normal subjects: Correlation to disc size, age, and ethnicity

Barbara C. Marsh, Louis Cantor, Darrell WuDunn, Joni Hoop, Jennifer Lipyanik, Vincent Michael Patella, Donald L. Budenz, David S. Greenfield, Jonathan Savell, Joel S. Schuman, Rohit Varma

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

PURPOSE: To study optic nerve head (ONH) topography parameters measured by Stratus optical coherence tomography (OCT) in normal subjects and to analyze ONH data for differences in relation to disc size, ethnicity, and age. METHODS: Three hundred sixty-seven normal subjects underwent Stratus optical coherence tomography ONH measurement using the fast optic disc scan protocol software package 3.0. Only ONH scans meeting specific qualification criteria were included for data analysis ensuring appropriate scan quality and reliability. ONH topographic parameters of qualified scans were analyzed for differences in regards to optic disc size, age, and ethnicity. RESULTS: Two hundred and twelve qualified ONH scans were included for data analysis. Mean disc area was 2.27±0.41 mm<sup>2</sup> and optic cup area, rim area, and horizontal integrated rim width increased with disc size, whereas vertical integrated rim area did not. Vertical integrated rim area, horizontal integrated rim width, and rim area decreased and cup area increased with age. Mean optic disc area was larger in African-Americans as compared with Hispanics or Whites and this difference was statistically significant. CONCLUSIONS: Optic cup area, rim area, and horizontal integrated rim width correlated to disc size. Vertical integrated rim area, horizontal integrated rim width, rim area, and cup area, changed with age. African-American optic discs had larger disc area measurements as compared with Whites optic discs and this difference was statistically significant.

Original languageEnglish
Pages (from-to)310-318
Number of pages9
JournalJournal of Glaucoma
Volume19
Issue number5
DOIs
StatePublished - 2010

Fingerprint

Optic Disk
Optical Coherence Tomography
African Americans
Hispanic Americans
Software

Keywords

  • Normals
  • Optic nerve head
  • Stratus OCT
  • Topography

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)

Cite this

Optic nerve head (ONH) topographic analysis by stratus OCT in normal subjects : Correlation to disc size, age, and ethnicity. / Marsh, Barbara C.; Cantor, Louis; WuDunn, Darrell; Hoop, Joni; Lipyanik, Jennifer; Patella, Vincent Michael; Budenz, Donald L.; Greenfield, David S.; Savell, Jonathan; Schuman, Joel S.; Varma, Rohit.

In: Journal of Glaucoma, Vol. 19, No. 5, 2010, p. 310-318.

Research output: Contribution to journalArticle

Marsh, BC, Cantor, L, WuDunn, D, Hoop, J, Lipyanik, J, Patella, VM, Budenz, DL, Greenfield, DS, Savell, J, Schuman, JS & Varma, R 2010, 'Optic nerve head (ONH) topographic analysis by stratus OCT in normal subjects: Correlation to disc size, age, and ethnicity', Journal of Glaucoma, vol. 19, no. 5, pp. 310-318. https://doi.org/10.1097/IJG.0b013e3181b6e5cd
Marsh, Barbara C. ; Cantor, Louis ; WuDunn, Darrell ; Hoop, Joni ; Lipyanik, Jennifer ; Patella, Vincent Michael ; Budenz, Donald L. ; Greenfield, David S. ; Savell, Jonathan ; Schuman, Joel S. ; Varma, Rohit. / Optic nerve head (ONH) topographic analysis by stratus OCT in normal subjects : Correlation to disc size, age, and ethnicity. In: Journal of Glaucoma. 2010 ; Vol. 19, No. 5. pp. 310-318.
@article{54d0164270c24c2b917e0b6fb03cddd0,
title = "Optic nerve head (ONH) topographic analysis by stratus OCT in normal subjects: Correlation to disc size, age, and ethnicity",
abstract = "PURPOSE: To study optic nerve head (ONH) topography parameters measured by Stratus optical coherence tomography (OCT) in normal subjects and to analyze ONH data for differences in relation to disc size, ethnicity, and age. METHODS: Three hundred sixty-seven normal subjects underwent Stratus optical coherence tomography ONH measurement using the fast optic disc scan protocol software package 3.0. Only ONH scans meeting specific qualification criteria were included for data analysis ensuring appropriate scan quality and reliability. ONH topographic parameters of qualified scans were analyzed for differences in regards to optic disc size, age, and ethnicity. RESULTS: Two hundred and twelve qualified ONH scans were included for data analysis. Mean disc area was 2.27±0.41 mm2 and optic cup area, rim area, and horizontal integrated rim width increased with disc size, whereas vertical integrated rim area did not. Vertical integrated rim area, horizontal integrated rim width, and rim area decreased and cup area increased with age. Mean optic disc area was larger in African-Americans as compared with Hispanics or Whites and this difference was statistically significant. CONCLUSIONS: Optic cup area, rim area, and horizontal integrated rim width correlated to disc size. Vertical integrated rim area, horizontal integrated rim width, rim area, and cup area, changed with age. African-American optic discs had larger disc area measurements as compared with Whites optic discs and this difference was statistically significant.",
keywords = "Normals, Optic nerve head, Stratus OCT, Topography",
author = "Marsh, {Barbara C.} and Louis Cantor and Darrell WuDunn and Joni Hoop and Jennifer Lipyanik and Patella, {Vincent Michael} and Budenz, {Donald L.} and Greenfield, {David S.} and Jonathan Savell and Schuman, {Joel S.} and Rohit Varma",
year = "2010",
doi = "10.1097/IJG.0b013e3181b6e5cd",
language = "English",
volume = "19",
pages = "310--318",
journal = "Journal of Glaucoma",
issn = "1057-0829",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Optic nerve head (ONH) topographic analysis by stratus OCT in normal subjects

T2 - Correlation to disc size, age, and ethnicity

AU - Marsh, Barbara C.

AU - Cantor, Louis

AU - WuDunn, Darrell

AU - Hoop, Joni

AU - Lipyanik, Jennifer

AU - Patella, Vincent Michael

AU - Budenz, Donald L.

AU - Greenfield, David S.

AU - Savell, Jonathan

AU - Schuman, Joel S.

AU - Varma, Rohit

PY - 2010

Y1 - 2010

N2 - PURPOSE: To study optic nerve head (ONH) topography parameters measured by Stratus optical coherence tomography (OCT) in normal subjects and to analyze ONH data for differences in relation to disc size, ethnicity, and age. METHODS: Three hundred sixty-seven normal subjects underwent Stratus optical coherence tomography ONH measurement using the fast optic disc scan protocol software package 3.0. Only ONH scans meeting specific qualification criteria were included for data analysis ensuring appropriate scan quality and reliability. ONH topographic parameters of qualified scans were analyzed for differences in regards to optic disc size, age, and ethnicity. RESULTS: Two hundred and twelve qualified ONH scans were included for data analysis. Mean disc area was 2.27±0.41 mm2 and optic cup area, rim area, and horizontal integrated rim width increased with disc size, whereas vertical integrated rim area did not. Vertical integrated rim area, horizontal integrated rim width, and rim area decreased and cup area increased with age. Mean optic disc area was larger in African-Americans as compared with Hispanics or Whites and this difference was statistically significant. CONCLUSIONS: Optic cup area, rim area, and horizontal integrated rim width correlated to disc size. Vertical integrated rim area, horizontal integrated rim width, rim area, and cup area, changed with age. African-American optic discs had larger disc area measurements as compared with Whites optic discs and this difference was statistically significant.

AB - PURPOSE: To study optic nerve head (ONH) topography parameters measured by Stratus optical coherence tomography (OCT) in normal subjects and to analyze ONH data for differences in relation to disc size, ethnicity, and age. METHODS: Three hundred sixty-seven normal subjects underwent Stratus optical coherence tomography ONH measurement using the fast optic disc scan protocol software package 3.0. Only ONH scans meeting specific qualification criteria were included for data analysis ensuring appropriate scan quality and reliability. ONH topographic parameters of qualified scans were analyzed for differences in regards to optic disc size, age, and ethnicity. RESULTS: Two hundred and twelve qualified ONH scans were included for data analysis. Mean disc area was 2.27±0.41 mm2 and optic cup area, rim area, and horizontal integrated rim width increased with disc size, whereas vertical integrated rim area did not. Vertical integrated rim area, horizontal integrated rim width, and rim area decreased and cup area increased with age. Mean optic disc area was larger in African-Americans as compared with Hispanics or Whites and this difference was statistically significant. CONCLUSIONS: Optic cup area, rim area, and horizontal integrated rim width correlated to disc size. Vertical integrated rim area, horizontal integrated rim width, rim area, and cup area, changed with age. African-American optic discs had larger disc area measurements as compared with Whites optic discs and this difference was statistically significant.

KW - Normals

KW - Optic nerve head

KW - Stratus OCT

KW - Topography

UR - http://www.scopus.com/inward/record.url?scp=77954001149&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954001149&partnerID=8YFLogxK

U2 - 10.1097/IJG.0b013e3181b6e5cd

DO - 10.1097/IJG.0b013e3181b6e5cd

M3 - Article

C2 - 19855299

AN - SCOPUS:77954001149

VL - 19

SP - 310

EP - 318

JO - Journal of Glaucoma

JF - Journal of Glaucoma

SN - 1057-0829

IS - 5

ER -