Optical mapping of the effect of pacing rate and I kr blocker, Dofetilide, on heterogeneity of action potential duration between rabbit right and left ventricle

Lin Yang, Li Li, Hong Mei Sun, Shu Kong, Zhao Yang, Hong Zhang, Shien-Fong Lin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In homogeneity of cardiac electro physiology is existed in both normal and diseased hearts, which would be exacerbated by electrical or structural remodeling. Slow heart rate or decreasing repolarization reserve of action potential can enhance transmural heterogeneity and promote arrhythmia generation. In this study, we used optical mapping technique to investigate how pacing rate changing and Ikr blocker, Dofetilide, influence the heterogeneity of action potential duration between rabbit right and left ventricle simultaneously. The results showed that slowing pacing rate might increase the heterogeneity of inter-ventricles and there were early after depolarization (EAD) happening in right ventricle and inducing trigged activity in left ventricle at BCL of 2000ms. 30 nmol/L Dofetilide could prolong the APD in both right and left ventricle markedly at BCL of 2000, 1000, and 500ms. However, the increment of APD in right ventricle was 226 ± 96ms, and in left ventricle was 213 ± 100ms at BCL of 1000 ms, which demonstrated that Dofetilide did not increase the heterogeneity between two ventricles significantly (P > 0.05). The results suggested Dofetilide inducing Torsades de points (Tdp) because of increasing transmural dispersion of repolarization (TDR), instead of increasing heterogeneity between right and left ventricle.

Original languageEnglish
Title of host publicationProceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012
Pages393-395
Number of pages3
DOIs
StatePublished - 2012
Event2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012 - Macau, China
Duration: May 28 2012May 30 2012

Other

Other2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012
CountryChina
CityMacau
Period5/28/125/30/12

Fingerprint

Action Potentials
Heart Ventricles
Rabbits
Depolarization
pamidronate
dofetilide
Cardiac Arrhythmias
Heart Diseases
Heart Rate
Cardiac Electrophysiology

Keywords

  • Dofetilide
  • heterogeneity
  • Optical mapping
  • pacing rate dependence
  • ventricular arrhythmia

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering

Cite this

Yang, L., Li, L., Sun, H. M., Kong, S., Yang, Z., Zhang, H., & Lin, S-F. (2012). Optical mapping of the effect of pacing rate and I kr blocker, Dofetilide, on heterogeneity of action potential duration between rabbit right and left ventricle. In Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012 (pp. 393-395). [6245137] https://doi.org/10.1109/iCBEB.2012.289

Optical mapping of the effect of pacing rate and I kr blocker, Dofetilide, on heterogeneity of action potential duration between rabbit right and left ventricle. / Yang, Lin; Li, Li; Sun, Hong Mei; Kong, Shu; Yang, Zhao; Zhang, Hong; Lin, Shien-Fong.

Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012. 2012. p. 393-395 6245137.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yang, L, Li, L, Sun, HM, Kong, S, Yang, Z, Zhang, H & Lin, S-F 2012, Optical mapping of the effect of pacing rate and I kr blocker, Dofetilide, on heterogeneity of action potential duration between rabbit right and left ventricle. in Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012., 6245137, pp. 393-395, 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012, Macau, China, 5/28/12. https://doi.org/10.1109/iCBEB.2012.289
Yang L, Li L, Sun HM, Kong S, Yang Z, Zhang H et al. Optical mapping of the effect of pacing rate and I kr blocker, Dofetilide, on heterogeneity of action potential duration between rabbit right and left ventricle. In Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012. 2012. p. 393-395. 6245137 https://doi.org/10.1109/iCBEB.2012.289
Yang, Lin ; Li, Li ; Sun, Hong Mei ; Kong, Shu ; Yang, Zhao ; Zhang, Hong ; Lin, Shien-Fong. / Optical mapping of the effect of pacing rate and I kr blocker, Dofetilide, on heterogeneity of action potential duration between rabbit right and left ventricle. Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012. 2012. pp. 393-395
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