Optimal screening strategy design for chlamydia infection among young women

Yu Teng, Nan Kong, Wanzhu Tu

Research output: Contribution to conferencePaper

Abstract

Chlamydia infection (CT) is caused by the bacterium, Chlamydia trachomatis, and is one of the most commonly reported sexually transmitted diseases (STDs) in the United States. CT is a "silent" disease with the majority of infected people having no symptoms. It can progress to serious reproductive and other health problems with both short-term and long-term consequences. However, it can be accurately diagnosed through lab tests and then effectively treated with antibiotics. The Centers for Disease Control and Prevention (CDC) recommends a screening strategy that carries yearly CT testing of all sexually active women age 25 or younger, older women with risk factors, and all pregnant women. However, there is no evidence-based justification of the optimality of this strategy in terms of cost-effectiveness. In this paper, we develop a discrete-time dynamic model for CT transmission and screening. We divide the population into compartments by their infectious status (i.e., normal, infected and recovered). We assume that unprotected sexual activity and infection risk per unprotected sex depend on age. We consider CT screening as an effective intervention, which may be applied at different age points. We compare different screening strategies in terms of cost-effectiveness and make recommendations on the strategy design.

Original languageEnglish (US)
StatePublished - Jan 1 2011
Event61st Annual Conference and Expo of the Institute of Industrial Engineers - Reno, NV, United States
Duration: May 21 2011May 25 2011

Other

Other61st Annual Conference and Expo of the Institute of Industrial Engineers
CountryUnited States
CityReno, NV
Period5/21/115/25/11

Keywords

  • Chlamydia trachomatis
  • Cost-effectiveness
  • Disease diagnosis
  • Mathematical model
  • Sexually transmitted disease

ASJC Scopus subject areas

  • Industrial and Manufacturing Engineering

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  • Cite this

    Teng, Y., Kong, N., & Tu, W. (2011). Optimal screening strategy design for chlamydia infection among young women. Paper presented at 61st Annual Conference and Expo of the Institute of Industrial Engineers, Reno, NV, United States.