Optogenetics and its application in neural degeneration and regeneration

Josue D. Ordaz, Wei Wu, Xiao Ming Xu

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Neural degeneration and regeneration are important topics in neurological diseases. There are limited options for therapeutic interventions in neurological diseases that provide simultaneous spatial and temporal control of neurons. This drawback increases side effects due to non-specific targeting. Optogenetics is a technology that allows precise spatial and temporal control of cells. Therefore, this technique has high potential as a therapeutic strategy for neurological diseases. Even though the application of optogenetics in understanding brain functional organization and complex behaviour states have been elaborated, reviews of its therapeutic potential especially in neurodegeneration and regeneration are still limited. This short review presents representative work in optogenetics in disease models such as spinal cord injury, multiple sclerosis, epilepsy, Alzheimer’s disease and Parkinson’s disease. It is aimed to provide a broader perspective on optogenetic therapeutic potential in neurodegeneration and neural regeneration.

Original languageEnglish (US)
Pages (from-to)1197-1209
Number of pages13
JournalNeural Regeneration Research
Volume12
Issue number8
DOIs
StatePublished - Aug 2017

Keywords

  • Alzheimer’s disease
  • Epilepsy
  • Light-activated proteins
  • Memory retrieval
  • Multiple sclerosis
  • Neural engineering
  • Neural plasticity
  • Neural regeneration
  • Neuron activation
  • Neuron inhibition
  • Parkinson’s disease
  • Spinal cord injury

ASJC Scopus subject areas

  • Developmental Neuroscience

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