Oral administration of L-arginine reduces intimal hyperplasia in balloon-injured rat carotid arteries

Changyi Chen, Samer G. Mattar, Alan B. Lumsden

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Endogenous nitric oxide (NO) is produced from L-arginine by NO synthase. We evaluated the effect of oral administration of L-arginine on intimal hyperplasia in balloon-injured rat carotid arteries. Thirty Sprague-Dawley rats underwent balloon denudation on the left common carotid artery. Fifteen rats were treated with L-arginine in drinking water (2.5 mg/mL) two days before injury and were continued for 2 weeks. Another 15 rats served as controls. All animals survived without complications or body weight loss. In the treated group, daily intake of L-arginine was 170 ± 43 mg/day. Plasma arginine levels were 130 ± 32 μmol/L prior to L-arginine intake, 165 ± 42 μmol/L at the day of injury, and 162 ± 26 μmol/L at sacrifice. Intimal hyperplasia developed in all balloon-injured arteries in both control and L- arginine-treated animals. However, L-arginine-treated animals showed a 65% reduction of the intima/media area ratio and a 26% reduction of the intimal cell proliferation compared with control animals. These data indicate that adequate amounts of L-arginine were ingested by the rats and that oral administration of L-arginine significantly reduced intimal hyperplasia of balloon-injured arteries without any detectable toxicity.

Original languageEnglish (US)
Pages (from-to)17-23
Number of pages7
JournalJournal of Surgical Research
Volume82
Issue number1
DOIs
StatePublished - Mar 1999
Externally publishedYes

Fingerprint

Tunica Intima
Carotid Arteries
Hyperplasia
Oral Administration
Arginine
Arteries
Common Carotid Artery
Wounds and Injuries
Nitric Oxide Synthase
Drinking Water
Sprague Dawley Rats
Weight Loss
Nitric Oxide
Body Weight
Cell Proliferation

Keywords

  • Cell proliferation
  • Intimal hyperplasia
  • L-arginine
  • Nitric oxide
  • Rat

ASJC Scopus subject areas

  • Surgery

Cite this

Oral administration of L-arginine reduces intimal hyperplasia in balloon-injured rat carotid arteries. / Chen, Changyi; Mattar, Samer G.; Lumsden, Alan B.

In: Journal of Surgical Research, Vol. 82, No. 1, 03.1999, p. 17-23.

Research output: Contribution to journalArticle

Chen, Changyi ; Mattar, Samer G. ; Lumsden, Alan B. / Oral administration of L-arginine reduces intimal hyperplasia in balloon-injured rat carotid arteries. In: Journal of Surgical Research. 1999 ; Vol. 82, No. 1. pp. 17-23.
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