Oral and dental late effects in survivors of childhood cancer

A Children's Oncology Group report

Karen E. Effinger, Cesar A. Migliorati, Melissa M. Hudson, Kevin P. McMullen, Sue C. Kaste, Kathy Ruble, Gregory M T Guilcher, Ami J. Shah, Sharon M. Castellino

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Purpose: Multi-modality therapy has resulted in improved survival for childhood malignancies. The Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers provide practitioners with exposure- and risk-based recommendations for the surveillance and management of asymptomatic survivors who are at least 2 years from completion of therapy. This review outlines the pathophysiology and risks for oral and dental late effects in pediatric cancer survivors and the rationale for oral and dental screening recommended by the Children's Oncology Group. Methods: An English literature search for oral and dental complications of childhood cancer treatment was undertaken via MEDLINE and encompassed January 1975 to January 2013. Proposed guideline content based on the literature review was approved by a multi-disciplinary panel of survivorship experts and scored according to a modified version of the National Comprehensive Cancer Network "Categories of Consensus" system. Results: The Children's Oncology Group oral-dental panel selected 85 relevant citations. Childhood cancer therapy may impact tooth development, salivary function, craniofacial development, and temporomandibular joint function placing some childhood cancer survivors at an increased risk for poor oral and dental health. Additionally, head and neck radiation and hematopoietic stem cell transplantation increase the risk of subsequent malignant neoplasms in the oral cavity. Survivors require routine dental care to evaluate for potential side effects and initiate early treatment. Conclusions: Certain childhood cancer survivors are at an increased risk for poor oral and dental health. Early identification of oral and dental morbidity and early interventions can optimize health and quality of life.

Original languageEnglish
Pages (from-to)2009-2019
Number of pages11
JournalSupportive Care in Cancer
Volume22
Issue number7
DOIs
StatePublished - 2014

Fingerprint

Survivors
Tooth
Neoplasms
Oral Health
Guidelines
Literature
Therapeutics
Dental Care
Hematopoietic Stem Cell Transplantation
Temporomandibular Joint
MEDLINE
Mouth
Young Adult
Neck
Survival Rate
Head
Quality of Life
Radiation
Pediatrics
Morbidity

Keywords

  • Late effects
  • Oral dental health
  • Pediatric cancer
  • Survivorship

ASJC Scopus subject areas

  • Oncology

Cite this

Effinger, K. E., Migliorati, C. A., Hudson, M. M., McMullen, K. P., Kaste, S. C., Ruble, K., ... Castellino, S. M. (2014). Oral and dental late effects in survivors of childhood cancer: A Children's Oncology Group report. Supportive Care in Cancer, 22(7), 2009-2019. https://doi.org/10.1007/s00520-014-2260-x

Oral and dental late effects in survivors of childhood cancer : A Children's Oncology Group report. / Effinger, Karen E.; Migliorati, Cesar A.; Hudson, Melissa M.; McMullen, Kevin P.; Kaste, Sue C.; Ruble, Kathy; Guilcher, Gregory M T; Shah, Ami J.; Castellino, Sharon M.

In: Supportive Care in Cancer, Vol. 22, No. 7, 2014, p. 2009-2019.

Research output: Contribution to journalArticle

Effinger, KE, Migliorati, CA, Hudson, MM, McMullen, KP, Kaste, SC, Ruble, K, Guilcher, GMT, Shah, AJ & Castellino, SM 2014, 'Oral and dental late effects in survivors of childhood cancer: A Children's Oncology Group report', Supportive Care in Cancer, vol. 22, no. 7, pp. 2009-2019. https://doi.org/10.1007/s00520-014-2260-x
Effinger, Karen E. ; Migliorati, Cesar A. ; Hudson, Melissa M. ; McMullen, Kevin P. ; Kaste, Sue C. ; Ruble, Kathy ; Guilcher, Gregory M T ; Shah, Ami J. ; Castellino, Sharon M. / Oral and dental late effects in survivors of childhood cancer : A Children's Oncology Group report. In: Supportive Care in Cancer. 2014 ; Vol. 22, No. 7. pp. 2009-2019.
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