Oral bone loss is increased in ovariectomized rats.

J. A. Gilles, D. L. Carnes, M. R. Dallas, S. C. Holt, Lynda Bonewald

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Alveolar bone loss associated with periodontal disease occurs frequently in postmenopausal females, the same group that is predisposed to osteoporosis. To determine if the estrogen-deficient state enhances oral bone loss, we studied ovariectomized rats administered the potent bone-resorbing cytokine interleukin-1 or the periodontal pathogen Campylobacter rectus lipopolysaccharide (LPS). Distal root canals of first mandibular molars were instrumented with endodontic files, and bone resorbing factors were deposited and sealed into the root canal. Radiographs of periapical bone loss were evaluated using computer assisted image analysis to determine lesion size. Both interleukin-1 and C. rectus LPS caused a significant increase in lesion area in both ovariectomized and normal rats when compared with controls and a significant increase in ovariectomized animals compared to nonovariectomized animals receiving LPS. Using this endodontic model, we have demonstrated that estrogen deficiency results in increased oral bone loss in rats.

Original languageEnglish (US)
Pages (from-to)419-422
Number of pages4
JournalJournal of Endodontics
Volume23
Issue number7
StatePublished - Jul 1997
Externally publishedYes

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Campylobacter rectus
Bone and Bones
Lipopolysaccharides
Dental Pulp Cavity
Endodontics
Interleukin-1
Estrogens
Alveolar Bone Loss
Computer-Assisted Image Processing
Periodontal Diseases
Osteoporosis
Cytokines

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Gilles, J. A., Carnes, D. L., Dallas, M. R., Holt, S. C., & Bonewald, L. (1997). Oral bone loss is increased in ovariectomized rats. Journal of Endodontics, 23(7), 419-422.

Oral bone loss is increased in ovariectomized rats. / Gilles, J. A.; Carnes, D. L.; Dallas, M. R.; Holt, S. C.; Bonewald, Lynda.

In: Journal of Endodontics, Vol. 23, No. 7, 07.1997, p. 419-422.

Research output: Contribution to journalArticle

Gilles, JA, Carnes, DL, Dallas, MR, Holt, SC & Bonewald, L 1997, 'Oral bone loss is increased in ovariectomized rats.', Journal of Endodontics, vol. 23, no. 7, pp. 419-422.
Gilles JA, Carnes DL, Dallas MR, Holt SC, Bonewald L. Oral bone loss is increased in ovariectomized rats. Journal of Endodontics. 1997 Jul;23(7):419-422.
Gilles, J. A. ; Carnes, D. L. ; Dallas, M. R. ; Holt, S. C. ; Bonewald, Lynda. / Oral bone loss is increased in ovariectomized rats. In: Journal of Endodontics. 1997 ; Vol. 23, No. 7. pp. 419-422.
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