Oral candidiasis and Sjogren's syndrome

Armando Ernesto Soto-Rojas, Antonio Rafael Villa, José Sifuentes-Osornio, Donato Alarcón-Segovia, Arnoldo Kraus

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Objective. To determine the prevalence of oral candidiasis (OC) in patients with Sjogren's syndrome (SS), to identify oral signs and symptoms associated with OC, and to compare them with a healthy group. Methods. Patients with primary SS, and with SS associated with autoimmune disease were identified according to established criteria. Each individual had: (1) a questionnaire, (2) an oral clinical evaluation, (3) a set of microbiological tests: tongue smear, culture of tongue smear, and saliva sample. Diagnosis of OC was established with 2 positive results and the presence of any sign or symptom. Results. A total of 81 subjects were studied, 21 with primary SS, 29 secondary SS, and 31 healthy subjects. We diagnosed OC in 74% of patients with SS, which was statistically significant compared to the healthy group (23%) p < 0.001. Frequent symptoms associated with OC were increased sensitivity to spicy foods (58%) and unpleasant metallic taste (40%). Common signs of OC were erythematous lesion on the dorsum of the tongue (68%) and angular cheilitis (24%). Conclusion. Prevalence of OC was high in patients with SS. The frequency of signs and symptoms associated with OC may explain some of the clinical manifestations. If chronic erythematous OC is found in patients with SS an oral assessment at every appointment may help provide appropriate treatment.

Original languageEnglish (US)
Pages (from-to)911-915
Number of pages5
JournalJournal of Rheumatology
Issue number5
StatePublished - May 1 1998
Externally publishedYes


  • Oral candidiasis
  • Sjogren's syndrome
  • Xerostomia

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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