Oral health status in children with acute lymphoblastic leukemia

Fawad Javed, Achint Utreja, Fernanda O. Bello Correa, Mansour Al-Askar, Malik Hudieb, Faisal Qayyum, Abdulaziz Al-Rasheed, Khalid Almas, Khalid Al-Hezaimi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Leukemia is a malignancy of the bone marrow. Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and accounts for nearly 75% of all newly diagnosed leukemias and 25% of all malignancies in childhood. The aim of the present study was to review the oral health status in children with ALL. Databases were explored using various combinations of the following keywords: " acute lymphoblastic leukemia" , " children" , " inflammation" , " pediatric" , " periodontal disease" and " periodontitis" . Oral inflammatory conditions including chelitis, gingivitis, herpetic gingivostomatitis, mucositis, oral candidiasis, periodontitis and ulcerations are common manifestations in children with ALL. Results: Periodontal inflammatory conditions and oral mucositis were reported to be significantly higher in children with ALL as compared to healthy controls. Tooth morphological disorders including agenesis, microdontia, short roots and developmental defects in the enamel and dentin were more often observed in children with ALL as compared to healthy controls. Children with ALL have a reduced salivary flow rate, which makes them more susceptible to dental caries as compared to healthy children. Malocclusion due to microdontia may also trigger temporomandibular joint disorders in children with ALL; however, this relationship needs further investigations. Conclusion: Oral inflammatory conditions including mucositis and gingivitis are common in children with ALL as compared to healthy children. Tooth morphological disorders including microdontia and enamel and dentin are common manifestations in children with ALL.

Original languageEnglish (US)
Pages (from-to)303-309
Number of pages7
JournalCritical Reviews in Oncology/Hematology
Volume83
Issue number3
DOIs
StatePublished - Sep 2012
Externally publishedYes

Fingerprint

Oral Health
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Health Status
Gingivitis
Mucositis
Periodontitis
Dentin
Dental Enamel
Tooth
Leukemia
Herpetic Stomatitis
Pediatrics
Oral Candidiasis
Temporomandibular Joint Disorders
Neoplasms
Stomatitis
Malocclusion
Dental Caries
Periodontal Diseases
Bone Marrow

Keywords

  • Acute lymphoblastic leukemia
  • Children
  • Dental
  • Oral, and periodontal disease
  • Pediatric

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Geriatrics and Gerontology

Cite this

Javed, F., Utreja, A., Bello Correa, F. O., Al-Askar, M., Hudieb, M., Qayyum, F., ... Al-Hezaimi, K. (2012). Oral health status in children with acute lymphoblastic leukemia. Critical Reviews in Oncology/Hematology, 83(3), 303-309. https://doi.org/10.1016/j.critrevonc.2011.11.003

Oral health status in children with acute lymphoblastic leukemia. / Javed, Fawad; Utreja, Achint; Bello Correa, Fernanda O.; Al-Askar, Mansour; Hudieb, Malik; Qayyum, Faisal; Al-Rasheed, Abdulaziz; Almas, Khalid; Al-Hezaimi, Khalid.

In: Critical Reviews in Oncology/Hematology, Vol. 83, No. 3, 09.2012, p. 303-309.

Research output: Contribution to journalArticle

Javed, F, Utreja, A, Bello Correa, FO, Al-Askar, M, Hudieb, M, Qayyum, F, Al-Rasheed, A, Almas, K & Al-Hezaimi, K 2012, 'Oral health status in children with acute lymphoblastic leukemia', Critical Reviews in Oncology/Hematology, vol. 83, no. 3, pp. 303-309. https://doi.org/10.1016/j.critrevonc.2011.11.003
Javed F, Utreja A, Bello Correa FO, Al-Askar M, Hudieb M, Qayyum F et al. Oral health status in children with acute lymphoblastic leukemia. Critical Reviews in Oncology/Hematology. 2012 Sep;83(3):303-309. https://doi.org/10.1016/j.critrevonc.2011.11.003
Javed, Fawad ; Utreja, Achint ; Bello Correa, Fernanda O. ; Al-Askar, Mansour ; Hudieb, Malik ; Qayyum, Faisal ; Al-Rasheed, Abdulaziz ; Almas, Khalid ; Al-Hezaimi, Khalid. / Oral health status in children with acute lymphoblastic leukemia. In: Critical Reviews in Oncology/Hematology. 2012 ; Vol. 83, No. 3. pp. 303-309.
@article{4fe1bb7ffc834fa4bc60d59d01f42a2d,
title = "Oral health status in children with acute lymphoblastic leukemia",
abstract = "Leukemia is a malignancy of the bone marrow. Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and accounts for nearly 75{\%} of all newly diagnosed leukemias and 25{\%} of all malignancies in childhood. The aim of the present study was to review the oral health status in children with ALL. Databases were explored using various combinations of the following keywords: {"} acute lymphoblastic leukemia{"} , {"} children{"} , {"} inflammation{"} , {"} pediatric{"} , {"} periodontal disease{"} and {"} periodontitis{"} . Oral inflammatory conditions including chelitis, gingivitis, herpetic gingivostomatitis, mucositis, oral candidiasis, periodontitis and ulcerations are common manifestations in children with ALL. Results: Periodontal inflammatory conditions and oral mucositis were reported to be significantly higher in children with ALL as compared to healthy controls. Tooth morphological disorders including agenesis, microdontia, short roots and developmental defects in the enamel and dentin were more often observed in children with ALL as compared to healthy controls. Children with ALL have a reduced salivary flow rate, which makes them more susceptible to dental caries as compared to healthy children. Malocclusion due to microdontia may also trigger temporomandibular joint disorders in children with ALL; however, this relationship needs further investigations. Conclusion: Oral inflammatory conditions including mucositis and gingivitis are common in children with ALL as compared to healthy children. Tooth morphological disorders including microdontia and enamel and dentin are common manifestations in children with ALL.",
keywords = "Acute lymphoblastic leukemia, Children, Dental, Oral, and periodontal disease, Pediatric",
author = "Fawad Javed and Achint Utreja and {Bello Correa}, {Fernanda O.} and Mansour Al-Askar and Malik Hudieb and Faisal Qayyum and Abdulaziz Al-Rasheed and Khalid Almas and Khalid Al-Hezaimi",
year = "2012",
month = "9",
doi = "10.1016/j.critrevonc.2011.11.003",
language = "English (US)",
volume = "83",
pages = "303--309",
journal = "Critical Reviews in Oncology/Hematology",
issn = "1040-8428",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Oral health status in children with acute lymphoblastic leukemia

AU - Javed, Fawad

AU - Utreja, Achint

AU - Bello Correa, Fernanda O.

AU - Al-Askar, Mansour

AU - Hudieb, Malik

AU - Qayyum, Faisal

AU - Al-Rasheed, Abdulaziz

AU - Almas, Khalid

AU - Al-Hezaimi, Khalid

PY - 2012/9

Y1 - 2012/9

N2 - Leukemia is a malignancy of the bone marrow. Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and accounts for nearly 75% of all newly diagnosed leukemias and 25% of all malignancies in childhood. The aim of the present study was to review the oral health status in children with ALL. Databases were explored using various combinations of the following keywords: " acute lymphoblastic leukemia" , " children" , " inflammation" , " pediatric" , " periodontal disease" and " periodontitis" . Oral inflammatory conditions including chelitis, gingivitis, herpetic gingivostomatitis, mucositis, oral candidiasis, periodontitis and ulcerations are common manifestations in children with ALL. Results: Periodontal inflammatory conditions and oral mucositis were reported to be significantly higher in children with ALL as compared to healthy controls. Tooth morphological disorders including agenesis, microdontia, short roots and developmental defects in the enamel and dentin were more often observed in children with ALL as compared to healthy controls. Children with ALL have a reduced salivary flow rate, which makes them more susceptible to dental caries as compared to healthy children. Malocclusion due to microdontia may also trigger temporomandibular joint disorders in children with ALL; however, this relationship needs further investigations. Conclusion: Oral inflammatory conditions including mucositis and gingivitis are common in children with ALL as compared to healthy children. Tooth morphological disorders including microdontia and enamel and dentin are common manifestations in children with ALL.

AB - Leukemia is a malignancy of the bone marrow. Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and accounts for nearly 75% of all newly diagnosed leukemias and 25% of all malignancies in childhood. The aim of the present study was to review the oral health status in children with ALL. Databases were explored using various combinations of the following keywords: " acute lymphoblastic leukemia" , " children" , " inflammation" , " pediatric" , " periodontal disease" and " periodontitis" . Oral inflammatory conditions including chelitis, gingivitis, herpetic gingivostomatitis, mucositis, oral candidiasis, periodontitis and ulcerations are common manifestations in children with ALL. Results: Periodontal inflammatory conditions and oral mucositis were reported to be significantly higher in children with ALL as compared to healthy controls. Tooth morphological disorders including agenesis, microdontia, short roots and developmental defects in the enamel and dentin were more often observed in children with ALL as compared to healthy controls. Children with ALL have a reduced salivary flow rate, which makes them more susceptible to dental caries as compared to healthy children. Malocclusion due to microdontia may also trigger temporomandibular joint disorders in children with ALL; however, this relationship needs further investigations. Conclusion: Oral inflammatory conditions including mucositis and gingivitis are common in children with ALL as compared to healthy children. Tooth morphological disorders including microdontia and enamel and dentin are common manifestations in children with ALL.

KW - Acute lymphoblastic leukemia

KW - Children

KW - Dental

KW - Oral, and periodontal disease

KW - Pediatric

UR - http://www.scopus.com/inward/record.url?scp=84864945749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864945749&partnerID=8YFLogxK

U2 - 10.1016/j.critrevonc.2011.11.003

DO - 10.1016/j.critrevonc.2011.11.003

M3 - Article

VL - 83

SP - 303

EP - 309

JO - Critical Reviews in Oncology/Hematology

JF - Critical Reviews in Oncology/Hematology

SN - 1040-8428

IS - 3

ER -