Oral vaccination of animals with antigens encapsulated in alginate microspheres

T. L. Bowersock, Harm HogenEsch, M. Suckow, P. Guimond, S. Martin, D. Borie, S. Torregrosa, H. Park, K. Park

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Most infectious diseases begin at a mucosal surface. Prevention of infection must therefore consider ways to enhance local immunity to prevent the attachment and invasion of microbes. Despite this understanding, most vaccines depend on parenterally administered vaccines that induce a circulating immune response that often does not cross to mucosal sites. Administration of vaccines to mucosal sites induces local immunity. To be effective requires that antigen be administered often. This is not always practical depending on the site where protection is needed, nor comfortable to the patient. Not all mucosal sites have inductive lymphoid tissue present as well. Oral administration is easy to do, is well accepted by humans and animals and targets the largest inductive lymphoid tissue in the body in the intestine. Oral administration of antigen requires protection of antigen from the enzymes and pH of the stomach. Polymeric delivery systems are under investigation to deliver vaccines to the intestine while protecting them from adverse conditions that could adversely affect the antigens. They also can enhance delivery of antigen specifically to the inductive lymphoid tissue. Sodium alginate is a readily available, inexpensive polymer that can be used to encapsulate a wide variety of antigens under mild conditions. Orally administered alginate microspheres containing antigen have successfully induced immunity in mice to enteric (rotavirus) pathogens and in the respiratory tract in cattle with a model antigen (ovalbumin). This delivery system offers a safe, effective means of orally vaccinating large numbers of animals (and perhaps humans) to a variety of infectious agents.

Original languageEnglish (US)
Pages (from-to)1804-1811
Number of pages8
JournalVaccine
Volume17
Issue number13-14
DOIs
StatePublished - Jan 1999
Externally publishedYes

Fingerprint

oral vaccination
alginates
Microspheres
Vaccination
antigens
Antigens
animals
Lymphoid Tissue
Vaccines
vaccines
Immunity
immunity
oral administration
Intestines
Oral Administration
intestines
sodium alginate
alginic acid
pathogens
Rotavirus

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Bowersock, T. L., HogenEsch, H., Suckow, M., Guimond, P., Martin, S., Borie, D., ... Park, K. (1999). Oral vaccination of animals with antigens encapsulated in alginate microspheres. Vaccine, 17(13-14), 1804-1811. https://doi.org/10.1016/S0264-410X(98)00437-X

Oral vaccination of animals with antigens encapsulated in alginate microspheres. / Bowersock, T. L.; HogenEsch, Harm; Suckow, M.; Guimond, P.; Martin, S.; Borie, D.; Torregrosa, S.; Park, H.; Park, K.

In: Vaccine, Vol. 17, No. 13-14, 01.1999, p. 1804-1811.

Research output: Contribution to journalArticle

Bowersock, TL, HogenEsch, H, Suckow, M, Guimond, P, Martin, S, Borie, D, Torregrosa, S, Park, H & Park, K 1999, 'Oral vaccination of animals with antigens encapsulated in alginate microspheres', Vaccine, vol. 17, no. 13-14, pp. 1804-1811. https://doi.org/10.1016/S0264-410X(98)00437-X
Bowersock, T. L. ; HogenEsch, Harm ; Suckow, M. ; Guimond, P. ; Martin, S. ; Borie, D. ; Torregrosa, S. ; Park, H. ; Park, K. / Oral vaccination of animals with antigens encapsulated in alginate microspheres. In: Vaccine. 1999 ; Vol. 17, No. 13-14. pp. 1804-1811.
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