Oral vaccination with alginate microsphere systems

T. L. Bowersock, Harm HogenEsch, M. Suckow, R. E. Porter, R. Jackson, H. Park, K. Park

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Oral vaccination is a simple, efficient way of inducing immunity at mucosal surfaces. The slow development of oral vaccines has been mainly due to the lack of suitable delivery systems. We have used hydrogel microspheres to deliver various vaccines to several animal species by oral administration. Oral delivery of vaccines using alginate microspheres elicited the production of secretory IgA (sIgA) at the mucosal surfaces in mice, rabbits, and cattle. Oral vaccination of chicken resulted in an increased delayed type hypersensitivity, a cell-mediated immune response, indicating a positive response to the vaccine. Our studies have clearly shown that alginate microspheres are effective for the oral administration of vaccines.

Original languageEnglish (US)
Pages (from-to)209-220
Number of pages12
JournalJournal of Controlled Release
Volume39
Issue number2-3
DOIs
StatePublished - May 1996
Externally publishedYes

Fingerprint

Microspheres
Vaccination
Vaccines
Oral Administration
Secretory Immunoglobulin A
Mucosal Immunity
Hydrogel
Delayed Hypersensitivity
Chickens
alginic acid
Rabbits

Keywords

  • Alginate microsphere
  • Mucosal immunity
  • Oral vaccination
  • Secretory IgA

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Bowersock, T. L., HogenEsch, H., Suckow, M., Porter, R. E., Jackson, R., Park, H., & Park, K. (1996). Oral vaccination with alginate microsphere systems. Journal of Controlled Release, 39(2-3), 209-220. https://doi.org/10.1016/0168-3659(95)00155-7

Oral vaccination with alginate microsphere systems. / Bowersock, T. L.; HogenEsch, Harm; Suckow, M.; Porter, R. E.; Jackson, R.; Park, H.; Park, K.

In: Journal of Controlled Release, Vol. 39, No. 2-3, 05.1996, p. 209-220.

Research output: Contribution to journalArticle

Bowersock, TL, HogenEsch, H, Suckow, M, Porter, RE, Jackson, R, Park, H & Park, K 1996, 'Oral vaccination with alginate microsphere systems', Journal of Controlled Release, vol. 39, no. 2-3, pp. 209-220. https://doi.org/10.1016/0168-3659(95)00155-7
Bowersock, T. L. ; HogenEsch, Harm ; Suckow, M. ; Porter, R. E. ; Jackson, R. ; Park, H. ; Park, K. / Oral vaccination with alginate microsphere systems. In: Journal of Controlled Release. 1996 ; Vol. 39, No. 2-3. pp. 209-220.
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