Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology

Jae Joon Han, Martin H. Plawecki, Peter C. Doerschuk, Vijay A. Ramchandani, Sean O'Connor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Physiologically-based pharmacokinetic (PBPK) models have been used to describe the distribution and elimination characteristics of intravenous ethanol administration. Further, these models have been used to estimate the ethanol infusion profile required to prescribe a specific breath ethanol concentration time course in a specific human being, providing a platform upon which other pharmacokinetic and pharmacodynamic investigations are based. In these PBPK models, the equivalence of two different peripheral tissue models are shown and issues concerning the mass flow into the liver in comparison with ethanol metabolism in the liver are explained.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages5033-5036
Number of pages4
DOIs
StatePublished - 2006
Event28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States
Duration: Aug 30 2006Sep 3 2006

Other

Other28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
CountryUnited States
CityNew York, NY
Period8/30/069/3/06

Fingerprint

Pharmacokinetics
Physiology
Ordinary differential equations
Ethanol
Liver
Pharmacodynamics
Metabolism
Tissue

ASJC Scopus subject areas

  • Bioengineering

Cite this

Han, J. J., Plawecki, M. H., Doerschuk, P. C., Ramchandani, V. A., & O'Connor, S. (2006). Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (pp. 5033-5036). [4029183] https://doi.org/10.1109/IEMBS.2006.259570

Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology. / Han, Jae Joon; Plawecki, Martin H.; Doerschuk, Peter C.; Ramchandani, Vijay A.; O'Connor, Sean.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 5033-5036 4029183.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Han, JJ, Plawecki, MH, Doerschuk, PC, Ramchandani, VA & O'Connor, S 2006, Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings., 4029183, pp. 5033-5036, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06, New York, NY, United States, 8/30/06. https://doi.org/10.1109/IEMBS.2006.259570
Han JJ, Plawecki MH, Doerschuk PC, Ramchandani VA, O'Connor S. Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 5033-5036. 4029183 https://doi.org/10.1109/IEMBS.2006.259570
Han, Jae Joon ; Plawecki, Martin H. ; Doerschuk, Peter C. ; Ramchandani, Vijay A. ; O'Connor, Sean. / Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. pp. 5033-5036
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