Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology.

Jae Joon Han, Martin H. Plawecki, Peter C. Doerschuk, Vijay A. Ramchandani, Sean O'Connor

Research output: Contribution to journalArticle

Abstract

Physiologically-based pharmacokinetic (PBPK) models have been used to describe the distribution and elimination characteristics of intravenous ethanol administration. Further, these models have been used to estimate the ethanol infusion profile required to prescribe a specific breath ethanol concentration time course in a specific human being, providing a platform upon which other pharmacokinetic and pharmacodynamic investigations are based. In these PBPK models, the equivalence of two different peripheral tissue models are shown and issues concerning the mass flow into the liver in comparison with ethanol metabolism in the liver are explained.

Original languageEnglish (US)
Pages (from-to)5033-5036
Number of pages4
JournalConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
StatePublished - 2006
Externally publishedYes

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Pharmacokinetics
Physiology
Ordinary differential equations
Anatomy
Ethanol
Liver
Pharmacodynamics
Metabolism
Intravenous Administration
Tissue

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

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AU - O'Connor, Sean

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