Abstract
Purpose of Review: University of Wisconsin solution is currently the most commonly used solution for abdominal organ transplantation and is the standard to which newer solutions are compared. In recent years, we have witnessed the introduction of two alternative preservation solutions, histidine-tryptophan- ketoglutarate (HTK) solution and Celsior solution, into the transplant clinical arena. In this article, these solutions will be introduced, compared to University of Wisconsin solution and studies comparing their clinical outcomes to those of University of Wisconsin solution will be reviewed. Recent Findings: HTK solution has been scrutinized in the literature with two reports suggesting a possible increased incidence of allograft pancreatitis, but it has also been demonstrated in several single-center retrospective studies and in one randomized prospective study to be clinically similar to University of Wisconsin solution, at least with lower flush volumes and shorter ischemic times. Celsior solution has been compared in four studies (three of which were prospective randomized studies) to University of Wisconsin solution and found to be clinically similar, but all of these studies reported reasonably brief ischemia times. Summary: All three preservation solutions seem to perform equally well with shorter ischemia times (<12 h). There remains controversy regarding both Celsior solution and HTK solution with longer ischemia times, whereas University of Wisconsin solution seems to perform well even for more than 24 h of preservation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 116-122 |
| Number of pages | 7 |
| Journal | Current Opinion in Organ Transplantation |
| Volume | 16 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1 2011 |
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Keywords
- Celsior solution
- histidinetryptophanketoglutarate solution
- organ preservation
- pancreas transplantation
- University of Wisconsin solution
ASJC Scopus subject areas
- Immunology and Allergy
- Transplantation
Cite this
Organ preservation solutions for whole organ pancreas transplantation. / Fridell, Jonathan A.; Mangus, Richard S.; Powelson, John A.
In: Current Opinion in Organ Transplantation, Vol. 16, No. 1, 01.02.2011, p. 116-122.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Organ preservation solutions for whole organ pancreas transplantation
AU - Fridell, Jonathan A.
AU - Mangus, Richard S.
AU - Powelson, John A.
PY - 2011/2/1
Y1 - 2011/2/1
N2 - Purpose of Review: University of Wisconsin solution is currently the most commonly used solution for abdominal organ transplantation and is the standard to which newer solutions are compared. In recent years, we have witnessed the introduction of two alternative preservation solutions, histidine-tryptophan- ketoglutarate (HTK) solution and Celsior solution, into the transplant clinical arena. In this article, these solutions will be introduced, compared to University of Wisconsin solution and studies comparing their clinical outcomes to those of University of Wisconsin solution will be reviewed. Recent Findings: HTK solution has been scrutinized in the literature with two reports suggesting a possible increased incidence of allograft pancreatitis, but it has also been demonstrated in several single-center retrospective studies and in one randomized prospective study to be clinically similar to University of Wisconsin solution, at least with lower flush volumes and shorter ischemic times. Celsior solution has been compared in four studies (three of which were prospective randomized studies) to University of Wisconsin solution and found to be clinically similar, but all of these studies reported reasonably brief ischemia times. Summary: All three preservation solutions seem to perform equally well with shorter ischemia times (<12 h). There remains controversy regarding both Celsior solution and HTK solution with longer ischemia times, whereas University of Wisconsin solution seems to perform well even for more than 24 h of preservation.
AB - Purpose of Review: University of Wisconsin solution is currently the most commonly used solution for abdominal organ transplantation and is the standard to which newer solutions are compared. In recent years, we have witnessed the introduction of two alternative preservation solutions, histidine-tryptophan- ketoglutarate (HTK) solution and Celsior solution, into the transplant clinical arena. In this article, these solutions will be introduced, compared to University of Wisconsin solution and studies comparing their clinical outcomes to those of University of Wisconsin solution will be reviewed. Recent Findings: HTK solution has been scrutinized in the literature with two reports suggesting a possible increased incidence of allograft pancreatitis, but it has also been demonstrated in several single-center retrospective studies and in one randomized prospective study to be clinically similar to University of Wisconsin solution, at least with lower flush volumes and shorter ischemic times. Celsior solution has been compared in four studies (three of which were prospective randomized studies) to University of Wisconsin solution and found to be clinically similar, but all of these studies reported reasonably brief ischemia times. Summary: All three preservation solutions seem to perform equally well with shorter ischemia times (<12 h). There remains controversy regarding both Celsior solution and HTK solution with longer ischemia times, whereas University of Wisconsin solution seems to perform well even for more than 24 h of preservation.
KW - Celsior solution
KW - histidinetryptophanketoglutarate solution
KW - organ preservation
KW - pancreas transplantation
KW - University of Wisconsin solution
UR - http://www.scopus.com/inward/record.url?scp=78751620785&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78751620785&partnerID=8YFLogxK
U2 - 10.1097/MOT.0b013e3283424d06
DO - 10.1097/MOT.0b013e3283424d06
M3 - Article
C2 - 21150618
AN - SCOPUS:78751620785
VL - 16
SP - 116
EP - 122
JO - Current Opinion in Organ Transplantation
JF - Current Opinion in Organ Transplantation
SN - 1087-2418
IS - 1
ER -