Organophosphate poisoning

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Organophosphates are commonly used as pesticides around the world. Exposures to organophosphates cause a significant number of poisonings and deaths each year. Organophosphates bind and inhibit cholinesterase enzymes. Acute toxicity manifests as a cholinergic crisis with excessive glandular secretions, altered mental status, and weakness. Several delayed syndromes have also been associated with organophosphate exposure, including a myasthenic-like syndrome, peripheral neuropathies, neuropsychiatric abnormalities, and extrapyramidal disorders. Clinical features and management of organophosphate poisoning is reviewed with emphasis on those affecting the central and peripheral nervous system.

Original languageEnglish
Pages (from-to)197-204
Number of pages8
JournalSeminars in Neurology
Volume24
Issue number2
DOIs
StatePublished - Jun 2004

Fingerprint

Organophosphate Poisoning
Organophosphates
Basal Ganglia Diseases
Cholinesterases
Muscle Weakness
Peripheral Nervous System
Peripheral Nervous System Diseases
Pesticides
Poisoning
Cholinergic Agents
Central Nervous System
Enzymes

Keywords

  • Extrapyramidal parkinsonism
  • Insecticides
  • Intermediate syndrome
  • Neurobehavioral
  • Neuropathy
  • Organophosphate poisoning
  • Paralysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Organophosphate poisoning. / Rusyniak, Daniel; Nanagas, Kristine.

In: Seminars in Neurology, Vol. 24, No. 2, 06.2004, p. 197-204.

Research output: Contribution to journalArticle

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