Organophosphate poisoning

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations


Organophosphates are commonly used as pesticides around the world. Exposures to organophosphates cause a significant number of poisonings and deaths each year. Organophosphates bind and inhibit cholinesterase enzymes. Acute toxicity manifests as a cholinergic crisis with excessive glandular secretions, altered mental status, and weakness. Several delayed syndromes have also been associated with organophosphate exposure, including a myasthenic-like syndrome, peripheral neuropathies, neuropsychiatric abnormalities, and extrapyramidal disorders. Clinical features and management of organophosphate poisoning is reviewed with emphasis on those affecting the central and peripheral nervous system.

Original languageEnglish (US)
Pages (from-to)197-204
Number of pages8
JournalSeminars in neurology
Issue number2
StatePublished - Jun 1 2004


  • Extrapyramidal parkinsonism
  • Insecticides
  • Intermediate syndrome
  • Neurobehavioral
  • Neuropathy
  • Organophosphate poisoning
  • Paralysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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