Orthodontic mechanotransduction and the role of the P2X7 receptor

Rodrigo F. Viecilli, Thomas Katona, Jie Chen, James K. Hartsfield, W. Eugene Roberts

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Introduction: The P2X7 receptor plays a crucial role in bone biology and inflammation. Its main function is to promote necrotic tissue metabolism by ensuring a normal acute-phase inflammatory response. We used a mouse model to describe and compare orthodontic mechanotransduction in wild-type and P2X7 knock-out mice. Methods: By using finite element analysis, mouse orthodontic mechanics were scaled to produce typical human stress levels. External root resorption, bone modeling, and bone remodeling were analyzed with fluorescent bone labels, Masson trichrome stain, and microcomputed tomography. Relationships between the biologic responses and the calculated stresses were statistically tested and compared between mouse types. Results: There were direct relationships between certain stress magnitudes and root resorption and bone formation. Hyalinization and root and bone resorption were different in the 2 types of mice. Conclusions: Orthodontic responses are related to the principal stress patterns in the periodontal ligament, and the P2X7 receptor plays a significant role in their mechanotransduction.

Original languageEnglish (US)
JournalAmerican Journal of Orthodontics and Dentofacial Orthopedics
Volume135
Issue number6
DOIs
StatePublished - Jun 2009

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Purinergic P2X7 Receptors
Orthodontics
Root Resorption
Bone and Bones
Osteitis
X-Ray Microtomography
Periodontal Ligament
Finite Element Analysis
Acute-Phase Reaction
Bone Remodeling
Bone Resorption
Mechanics
Osteogenesis
Knockout Mice

ASJC Scopus subject areas

  • Orthodontics

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Orthodontic mechanotransduction and the role of the P2X7 receptor. / Viecilli, Rodrigo F.; Katona, Thomas; Chen, Jie; Hartsfield, James K.; Roberts, W. Eugene.

In: American Journal of Orthodontics and Dentofacial Orthopedics, Vol. 135, No. 6, 06.2009.

Research output: Contribution to journalArticle

Viecilli, Rodrigo F. ; Katona, Thomas ; Chen, Jie ; Hartsfield, James K. ; Roberts, W. Eugene. / Orthodontic mechanotransduction and the role of the P2X7 receptor. In: American Journal of Orthodontics and Dentofacial Orthopedics. 2009 ; Vol. 135, No. 6.
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