Oscillations of granulocytic and megakaryocytic progenitor cell populations in cyclic neutropenia in man

N. Jacobsen, Hal Broxmeyer

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The concentration of granulocytic progenitor cells in the bone marrow of 2 patients with cyclic neutropenia was assessed at intervals during the cycle. Synchronous oscillations were observed for cells forming neutrophilic and megakaryocytic colonies in diffusion chambers in vivo (CFU-D), suggesting a close relationship between the two cell types. However, an almost reverse relationship was observed between CFU-D and cells forming colonies in agar culture in vitro (CFU-C), which cycled out of phase with CFU-D. This supports the concept that CFU-D and CFU-C denote different cell types.

Original languageEnglish (US)
Pages (from-to)33-36
Number of pages4
JournalScandinavian Journal of Haematology
Volume23
Issue number1
StatePublished - 1979
Externally publishedYes

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Stem Cells
Population
Dilatation and Curettage
Somatostatin-Secreting Cells
Agar
Bone Marrow
Cyclic neutropenia
In Vitro Techniques

ASJC Scopus subject areas

  • Hematology

Cite this

Oscillations of granulocytic and megakaryocytic progenitor cell populations in cyclic neutropenia in man. / Jacobsen, N.; Broxmeyer, Hal.

In: Scandinavian Journal of Haematology, Vol. 23, No. 1, 1979, p. 33-36.

Research output: Contribution to journalArticle

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